Regions of the Chinese people's liberation army air force general hospital USES the therapy of traditional Chinese medicine treatment of diabetic nephropathy, the second army medical achievements won the 2015

Zi kidney t2dm method to improve diabetes renal function

Time: 2015-10-21

Source: China's traditional Chinese medicine

Author: xin-ying ma

Report from our correspondent By the Chinese people's liberation army air force general hospital regions angiotensin, director of the leading group, with support from the army subject of traditional Chinese medicine and so on many subjects, 15 years of "zi kidney t2dm method to research on the mechanism and application of treatment of diabetic nephropathy project has won second prize among the 2015 annual military medical outcomes.

Team through a lot of literature research, blends together the name old doctor of traditional Chinese medicine experience, and on the basis of clinical practice, put forward the development of diabetic nephropathy (DN), kidney empty collaterals is the basic pathogenesis of blood stasis resistance created zi kidney method of t2dm, and formulated the basic syndromes zi kidney t2dm.

Research illustrates the method of "zi kidney t2dm" approach, the mechanism of action of targets in the treatment of DN, the entities by animal and in vitro cell culture, etc. Series of experiment research, confirmed that the therapy can from the histology, cytology and molecular level level non enzymatic glycosylation, effectively restrain the kidney Ⅳ collagen type, adjust the TGF beta mRNA, MMP 2, MMP - 9, a variety of cytokines such as ET 1 mRNA, improve blood sugar, blood fat, ANP and ET, reducing urinary protein and other biological indicators, promote the improvement of the kidney tissue pathological structure, prevent and delay the occurrence and development of DN.

At the same time, the research proposed is given priority to with "zi kidney t2dm method" installment, classification treatment of DN, established by evidence-based medicine and traditional Chinese medicine combined treatment of syndrome classification model and evaluation system, and carried out respectively on diabetes early and decompensation period of prospective, randomized, controlled, and in traditional Chinese medicine syndrome differentiation stage (early, early, mid, and late), classification (qi and Yin deficiency, spleen and kidney, spleen and kidney Yang deficiency, liver and kidney Yin deficiency, Yin and Yang are two virtual) as the main line of clinical research.

Results showed that zi kidney t2dm method not only can effectively block and lower production, synthetic Ⅳ - C, repair glomerular basement membrane and mesangial cell matrix, reduce or prevent the generation of ANP and ET and secretion, improve the kidney damage capillary, prevent or delay the progress of glomerular sclerosis lesions, effective control of DN process of chronic renal failure, and in improving patients' renal function, reduce blood sugar, blood fat, adjust the body function state, restore body function, improve the quality of life in obvious effect, especially in the early DN, early and mid-term effects obvious, total effective rate was 86.50%, and the delay dialysis duration of 3 to 5 years at least, highlights the advantages of individualized treatment of traditional Chinese medicine clinical curative effect is superior to pure western medicine treatment, to reduce patients' symptoms, adjust the overall function and improve kidney function and delay the progression of outstanding performance, and it is safe to use relative.

Type 2 diabetes mellitus is a worldwide one of the most important chronic diseases endangering human health, as of 2010, the prevalence of type 2 diabetes mellitus has been as high as 11.6% adults in our country. Diabetic nephropathy (DN) is the one of the most common and most serious microvascular complications, the incidence of up to 20 ~ 40%, is a leading cause of death and disability, treatment is difficult.