Improve the thymus function or AIDS treatment new ideas

Healthday news (freelance reporter DuanWenLi) after long-term regular "cocktail" treatment in patients with AIDS, why there are a few of the patient not ideal control, the immune function can't be rebuilt? Beijing union medical college hospital and took five years LiTaiSheng professor more completed a study showing that, the immune function of patients with AIDS can rebuild, depending on the CD4 + T cells of the thymus freshmen and the number of group. This finding explains AIDS "immunology no response" produce mechanism, improve the thymus function or hints as AIDS treatment new ideas. The study related papers published recently in the clinical journal of infectious diseases.

Research found that, although in the good guarantee compliance premise accept "cocktail" treatment, plasma viral load a long time in the control of a level under, but still have the 5% ~ 30% of HIV patients CD4 + T immune cell number not significant growth in this kind of patients, the researchers will be defined as "immunology no response" person. These patients opportunistic infections disease incidence, HIV/AIDS incidence and mortality, etc are higher than the "immunology response well" patients.

Beijing union medical college hospital from cases in the library, the team were after the antiviral treatment "immunology no response" 17 and the "immunology response well" in 13 people as the research object, the CD4 + T cells to observe its innocence and group (this group of cells that increase immunity enhancement), the thymus freshman and group (CD31), and 5 cells and the group of a change in trend. The results found that no matter be "the immune response good" patients, or "immune no response" of the patients, the classic cocktail of therapy to increase the thymus and group of new role is not much; The thymus and the number of new of AIDS patients and the CD4 + T lymphocytes growth, a positive correlation between the immune function of patients with AIDS play the decisive role in the reconstruction, the thymus failure will cause "immunology no response" patients CD4 + T of pure no significant growth cells subsets.

LiTaiSheng introduction, this discovery is the important significance of AIDS patients, through the early detection of CD4 + T lymphocyte count and thymus proportion of new cells, can discern "immunology no response" person, without having to wait until after a period of treatment to be sure. For these patients, the new treatment strategies for "cocktail" in treatment at the same time, and strive to improve the thymus function.