Set up a system of party dose effect research scientific method

China's traditional Chinese medicine to

        The cold-induced febride taxonomy with the doctrine of the medicine clinical rational usage of enlightenment

        The cold-induced febride is the oldest materia medica book, according to the medicinal properties, efficacy and toxicity etc., will is divided into the upper, middle and under the doctrine of drugs. Where "prescription... the life, to day, non-toxic. More suits, long time don't hurt. To the intellectual man fit, yiqi, ageless live, on this sutra", "traditional Chinese medicine (TCM)... the Lord raises a gender, to people. Non-toxic, toxic, consider its appropriate. To halt the disease, tonify deficiency are reutilized, this condition", "the remedy to the case... the main cure, to the ground. Many poison, not for a long time. To not evil, accumulate, the more disease, under this sutra". Is not hard to find, in the first grade and the drugs including many medicine food homology of drugs, such as yam (yam), big jujube, coix seed, radix puerariae, platycodon grandiflorum, etc; Which resulted in more toxic drugs, such as aconite root and pinellia tuber, euphorbia kansui, spurge, crotonic, etc. Accordingly, "the sutra of drug classification with the doctrine of the principle for clinical reasonable use provides a train of thought:

        For similar ", "top grade" described by drugs, many can be used as a food or healthy food. These herbs usually mild, less adverse reaction, would be taken a long time. Widely planted in our country, can be made into all kinds of food, taste good, easy for patients to accept. These characteristics make food combination traditional Chinese medicine in clinic has a single, large doses of the application instance, to be both safe and effective. For this class of drugs, the threshold dose is relatively broad, and the drug dose threshold to include all the therapeutic window as soon as possible.

        For the similar of this sutra describes as "inferior" drugs, because that opened medicinal fierce or toxicity is bigger, so the clinical application have to be very cautious, strictly control the dosage range, avoid to produce serious adverse reactions.

        "Similar" this after "of" drugs, should according to the actual clinical choose the right dose, neither like can be used for food or health care food drug dosage range, let patients more suits, long suit, lead to adverse reactions; Don't too strict control the dose threshold, and that the therapeutic window not in dose threshold, affect the clinical curative effect.

        Is worth questioning. "classification" with the doctrine of reasonable ideas of modern clinical dosage have very good enlightenment function, but does not represent can truthfully according to "the classics" doctrine of classification to drug use. Doctrine of drugs, top grade contains toxic drugs, resulted in some non-toxic, even the medicine food homology of medicine. Such as, "this after" a book, is generally believed that Dan medicine has longevity prolong effect, therefore appeared in top grade such as cinnabar, cinnabar) such as toxic mineral drugs, with the development of science, people to this kind of mineral medicine toxicity understanding more deep, so, for this kind of top grade drugs, applications have to be very cautious.

        Traditional Chinese medicine authority dose regulation conflicts with the modern clinical dosage

        Pharmacopoeia, the code is the national drug standards, specifications, mainly used for drugs, the standard, to strengthen the drug quality supervision and management, ensure the quality and security of drug is safe and effective. Drug standards is a drug is an important part of modern production and quality management, pharmaceutical production, supply, use, supervision and administration department to follow the legal basis. Wrote in 1953 in China since the founding of the first "pharmacopoeia of the People's Republic of China, has been revised reprint nine times, the latest edition of 2010 edition of the People's Republic of China pharmacopoeia. Is divided into three parts, "the pharmacopoeia" of traditional Chinese medicine herbs and yinpian certain rules in the first, including the regulations on slices dosage and usage, as a result, the current "pharmacopoeia" is the highest standard of clinical dosage. 2010 edition of pharmacopoeia into slices 617 kinds, including 16 kinds of no prescribed doses, 1 species (boat-fruited sterculia) dose not in units of grams of stipulations. Of (among) all the slices, the most common minimum dose is 3 g, maximum dose is 10 grams.

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