With disease of strategy research 
 
 
Ji Yuhang Chen Xinyan Lian Fengmei China academy of traditional Chinese medicine hospital of the gate 
 
 
China's traditional Chinese medicine to 

    "With the disease of quantity" refers to the clinical syndrome differentiation and treatment process, the French side in determining drug, on the basis of the variety of symptom severity, flexible adjustment dose, the formulas in order to obtain a better curative effect.
 
    Most of the traditional Chinese medicine thinks, follow the "amount with disease" strategy can improve the clinical curative effect of diagnosis and treatment, reduce the side effects of drugs, enhance the patient's compliance. Therefore, this strategy is closely related to the curative effect of clinical diagnosis and treatment in the field of clinical research of traditional Chinese medicine has increasingly caused wide public concern. Statement "with the disease", scientifically and objectively explain "amount with disease diagnosis and treatment strategy of" scientific, is of great significance to clarify the clinical dose of TCM theory.
 
    "With the disease, however," clinical research and thinking strategy faces many challenges, such as according to change of what "disorder" to adjust the dosage? Choose what point to adjust drug dosage? How to adjust the dosage? How to evaluate a specific amount with disease strategy is scientific, etc. The lack of research path and method is bottleneck problem urgently to be solved in the study area.
 
    973 project "is given priority to with quantity - effect relationship of classic parties related basic research", in turn, adopted the classic content analysis, both doctors questionnaire investigation, clinical research data analysis and multicenter, randomized, double-blind clinical study, the study of "with syndrome of" strategy research path and method to carry out the system.
 
    Classic content analysis
 
    The study of "with syndrome of" strategy, from the traditional Chinese medicine classics, through literature analysis, summed up "with syndrome of" key elements. Research on medical sage zhang zhongjing treatise on febrile disease of the original text of synopsis of detailed classification, summary, found "with syndrome of" three elements - "indications" "time/inflection point" and "change".
 
    Adjust the dosage of indications include disease cured or not, presence or absence of a drug curative effect, the presence of adverse reactions, and the symptoms change or not. Adjust the dose of "time", zhongjing commonly used ", "" when" the original "hour". And how to adjust medicine "quantity", zhongjing generally adjusted according to the different response of patients with medication, such as the original amount is following suit, increase the dosage, stop medication, change a taste the dosage in the party.
 
    Three elements together, constitute the important content of the theory of TCM clinical dose: drug in the body after a certain time, initial curative effect continues to press the original dose medication; Get medicine curative effect is to stop; No effect, increase the dose, the symptoms changed the formula composition of doses is changed.
 
    Both doctors questionnaire
 
    In classic content analysis summary "along with the three elements of the amount of disease", for "quantity" with the disease of the people involved (doctors and patients), diabetes (chronic), infantile pneumonia (acute) as the demonstration diseases, with the method of cross-sectional survey, key elements of "with syndrome of" cognitive investigation, respectively by doctors, patients, with doctors focus on "influence the occurrence, development and outcome of disease" patients compliance "adverse reactions and patient care" effect "" security" and other indicators and timing as the core, the collection of indicators, through the analysis summary, form "with syndrome of" main basis "disease/indications" and "timing/inflection point".
 
    The results found that Chinese medicine treatment of diabetes, on the choice of "disease/indications", a doctor the most attention to the change of glycosylated hemoglobin, and patients the most attention to the change of fasting plasma glucose. To adjust the dosage of the timing/inflection point ", doctors believe should be in 2 weeks and people should think during 4 weeks focus on blood sugar, the change of symptoms, such as glucose, symptoms change did not reach the standard expected "efficient" or a "side effect", you will need to adjust the traditional Chinese medicine.
 
 
 
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