Chinese scientists decode the village card virus structure Is expected to develop specific

Release date: 2016-05-25

Source: the future network

Author: JinYing

The reporter learns 25, college of life science professor hai-tao Yang led the research team resolve the village card virus helicase 1.8 (el) high resolution crystal structure, is expected to develop a drug for the treatment of village card virus.

Village card heat is caused by the village card virus, a mosquito-borne infectious diseases, symptoms similar to those of dengue fever, including fever, rash, headache, joint pain, muscle pain, and the purulent conjunctivitis, etc. There is evidence that village card virus infection with fetal and neonatal microcephaly and some serious neurological complications. In February this year, the world health organization declared village card virus a "public health emergency of international concern", 33 countries reported village card the spread of the virus. However, there are no vaccine for this virus infection and effective treatments.

Helicase is one of the important targets for design of antiviral drugs. In the process of virus proliferation, helicase for almost all the necessary to viral replication proteins. Virus helicase and village card can get energy through hydrolysis nucleoside triphosphate, loose the virus nucleic acid chain. This is the village card is a basic steps to viral replication.

, the researchers said the village card virus specific activity sites as the key target helicase, is expected to stop viral replication and to prevent the virus infection, and for the development of inhibiting viral replication and control village card virus infected antiretroviral inhibitors laid the foundation.

According to introducing, hai-tao Yang team resolved village card virus helicase crystal structure, resolution of 1.8 (el). The high resolution structure reveals the key areas of nucleoside triphosphate hydrolysis, and accommodate RNA positive charge of the channel, for the village card virus drugs research and development to provide an accurate model. The findings, published online yesterday in the journal.