Huazhong university of science and technology professor Wang Ning team and the Chinese academy of sciences Shanghai YouJiSuo 俞飚 researcher team, synthesis and screening a common cell proliferation and metastasis of malignant tumor recycling has special curative effect, a new type of precise targeting drug molecules can be 100% kill the regeneration of cells, such as breast cancer, lung cancer in the future are likely to fundamentally improve the cure rate of cancer. Recently, the international authoritative magazine nature communications introduced the results of this medical research.
Cancer patients are fatal because of metastasis and proliferation of cancer cells, but how to inhibit metastasis or control the metastasis of cancer cells is still an unsolved problem.
Huazhong big Wang Ning jointly developed the team and the professor huang bo screening cancer metastasis former fierce - regenerative cell malignant tumor (cancer stem cell) of the new method, the results, published in 2012, the international authoritative journal nature materials.
The researchers found that these highly metastatic cancer cells were highly resistant, and that existing cancer drugs in the market could not kill these malignant cells. Since 2014, wang ning team and yu biao team have cooperated to synthesize and screen a novel targeted molecular drug with special therapeutic effect on the proliferation and metastasis of malignant tumor regenerated cells.
In a paper titled "new drugs to inhibit cancer stem cells," the researchers targeted the retinoic acid receptors of tumor cells and developed wyc-209 through the latest chemical synthesis.
The researchers found, WYC - 209 under the condition of low concentration can kill 100% of lung cancer, breast cancer, ovarian cancer, melanoma and other malignant tumor cells and inhibit the proliferation of malignant tumor stem cells. In mice, the researchers found that the drug could kill metastatic cancer cells and inhibit metastasis, with an effective rate of nearly 90 percent.
According to the introduction, wyc-209 is not only significantly superior to chemotherapy and targeted cancer drugs in domestic and foreign markets, but more importantly, both in vitro and animal experiments have shown that wyc-209 has no toxic side effects.
The researchers further studied how the drug works, and they found that the drug induced apoptosis in cancer cells through a cysteine protease-3 signaling pathway. Shanghai institute of organic chemistry and huazhong have jointly applied for Chinese patent and international patent. If wyc-209 is to pass clinical trials in the future, it may be possible to radically improve the cure rate of malignant tumor metastasis.
Author: our reporter qian zhongjun correspondent wei fuxiang.