Clinical traditional Chinese medicine mainly research about system biology

Medicine economic news

        As China's global medical market position increasingly ascending, Chinese traditional medicine globalization call gradually tall.

        In order to deeply explore new drug research and development strategy, and traditional Chinese medicine globalization direction, oct. 23 ~ 25, the guangxi zhuang autonomous region bureau of foreign experts affairs host, guangxi medicine chamber of commerce assisted, guangxi hui treasure source pharmaceutical co., LTD. Undertakes "creating new strategy and Chinese top international conference" held in nanning.

        In the opportunities and challenges of today, Chinese traditional medicine research and development needs more is a kind of idea of "variable.

        The expert points out, in the new drug research and development, the current thinking is not enough, did not need to have new ideas development; Among them, the traditional Chinese medicine has its unique features and status, the future may be most likely to obtain primitiveness innovation breakthrough field.

        Absorption and development

        The modernization of traditional Chinese medicine is a complex giant engineering. Due to the composition, more effective components and toxic component is not entirely clear and other reasons, the globalization of Chinese traditional medicine is still in the difficult exploration. So far, in the European Union to registered and listed mondial only efforts kang, the much-anticipated compound danshen drop pill is still in the United States for Ⅲ period clinical test.

        However, in recent years the rise of translational medicine just to clinical as the basis, the personalized therapy for characteristics of traditional Chinese medicine study provides a good opportunity for development.

        Because the traditional new medicine r&d risk is high, the degree of difficulty is big, long life cycle, costly, known from existing of traditional Chinese medicine, plant medicine, traditional Chinese medicine compound found that active material has good prospects for development.

        "Synergistic attenuated components compatibility, composition compatibility of traditional Chinese medicine research and development innovation, it is traditional Chinese medicine compound the sublimation of modern research and development. Chinese academy of medical sciences, deputy director of the institute of medicinal plants SunXiaoBo so evaluation.

        In SunXiaoBo opinion, network pharmacology is drug research and development of new mode: "in the past a single target to the research methods involved in a number of genes, many targets path and network control heart cerebrovascular disease and cancer complex has been difficult to work, new drug research and development success rate was reduced by 30%, high specificity target drug research and development of ideas are changing."

        In the 302th hospital of PLA army traditional Chinese and western pharmaceutical institute director xiao river is still in the conference pointed out that: "in new drug development, clinical experience. I think it is very important to the transformation of traditional Chinese medicine, clinical laboratory medicine is" - - "the transformation of western medicine, clinical medicine is more 'laboratory - clinical'."

        "Therefore, in the modernization of traditional Chinese medicine development, the transformation of driving industry should give priority to, to clinical guide primarily to shift." Shaw repeatedly stressed that the river.

        In addition, the United States, YaoLiXi Yale university professor, cancer research experts ZhengYongJi remind: "Chinese traditional medicine research must be in systems biology as a starting point."

        ZhengYongJi explanation: "in general, western medicine mainly from the molecular level, cell Angle to study the development of traditional Chinese medicine. Can be said to be go opposite path; but this is research and development idea must consider the question."

        In fact, systems biology thought is often considered transformation medical major technical support and theoretical sources, the application of system science can directly lead to basic medicine and clinical medicine greatly shorten the distance between.

        Meanwhile, due to the traditional Chinese medicine adhere to the overall concept and system thinking, these thoughts and system biology has a lot of similarities. Therefore, many scholars think system in TCM theory of traditional Chinese medicine is to describe a very effective tool.

        Homogeneity problem

        The expert inside course of study points out, the Chinese medicine to become scientific prescription, you must do three: with modern biological technology prove that it contains the disease produces curative effect of the biological activity material; To make the traditional experience into modern clinical practice, the application of the international general clinical research standard argumentation curative effect; The Chinese traditional medicine cultivation, collection to standardization, want to have internationally recognized quality standards.

        In fact, the modern Chinese medicine quality requirements, in the work of letter earlier this year issued by the pharmaceutical industry "1025" development planning "has repeatedly been stressed. "To improve and perfect the whole industry chain of traditional Chinese medicine of technical standards and specifications, and cultivate the exact curative effect, high security, dosage form is advanced, the quality is stable control of modern traditional Chinese medicine" and so on the requirement was added to the documents in.

        "In the source of planting on grasp, when the entire series developed, this is you unique product. Because no matter how good the prospect of traditional Chinese medicine, if do not have the resources, everything no way." ZhengYongJi suggestion at the meeting.

        To this, shaw, said the river, Chinese herbal medicine quality evaluation and control should take multiple comprehensive strategy, namely, to establish a based on many link, much index, quantitative and comprehensive evaluation of the Chinese herbal medicine control method system, to ensure the safety of Chinese, effectiveness and quality stability, and to promote the development of the modernization of traditional Chinese medicine to provide new scientific countermeasures and technical support.

        Combined with the research of medicinal materials production, shaw river and its team to create a set of relative history, production based on region ecological suitability, specification of goods grades, composition the golden ratio and biological effect (poison) price five elements comprehensive weighted Chinese herbal medicine pure sex and quality of quality comprehensive evaluation index -- "genuine index" (Dao - DiIndex, DDI).

        In addition, in the traditional Chinese medicine production, the feeding of Chinese herbal medicine base original producing area and not fixed, production process parameters of uncertainty for the final product quality will influence, even the same manufacturer the same variety of different batch quality differences between. Therefore, make every batch of preparation of traditional Chinese medicine out conform to "uniformity" principle is more important.

        "Drug only achieve" uniformity ", can effectively in clinical trials." ZhengYongJi pointed out: "but the domestic some enterprises in the quality control is not enough precise; therefore, each unit the result that come out can be different."

        In fact, after the release of the traditional Chinese medicine registered supplementary management stipulation "also proposed that" the development of new drug of TCM should conform to the theory of traditional Chinese medicine, pay attention to clinical practice foundation, has the clinical application value of traditional Chinese medicine, guarantee the safe and effective and stable quality uniform "concept request, expectations of traditional Chinese medicine herbs by determining the source, base the original purpose and process parameters, through the source, process and final index to control the quality of traditional Chinese medicine stable and uniform.

        In fact, systems biology thought is often considered transformation medical major technical support and theoretical sources, the application of system science can directly lead to basic medicine and clinical medicine of the distance between greatly shorten the (author: ou hui sensitive)