Traditional Chinese medicine (TCM) screening, structure characterization and quality control research the breakthrough

        Proceedings of China - (reporter sealing sail) reporter recently learned from the Chinese academy of sciences changchun institute of applied chemistry, this institute researchers using modern mass spectrometry method, and combined with other analytical techniques, carry out the traditional Chinese medicine (TCM) screening, structure, quality control problems, such as the innovation of the research, and a series of important progress has been made.

        It is understood that with the gradual integration of traditional Chinese medicine international medicine market, China's traditional Chinese medicine industry is facing enormous challenges and opportunities. Many traditional Chinese medicine products due to the weak basic research, play the material basis for the efficacy and active ingredient is not clear, the quality control standard is not standard, unable to realize the joint with the international market. Therefore, rely on modern science and technology, in-depth excavation of the treasure-house of traditional Chinese medicine scientific connotation, clarify the active ingredient of its efficacy play, set up quality control and evaluation methods related to the biological activity, make the traditional Chinese medicine really safe, effective and controllable quality, speed up the realization of modernization of Chinese medicine, is China's traditional Chinese medicine industry and scientific research be solved the key problem.

        Which should be of the Chinese academy of sciences changchun scientific research personnel through the study on innovation, set up with enzyme and nucleic acid biological target molecules interact with Chinese native medicine ingredient such as active ingredients of traditional Chinese medicine (TCM) on the basis of the screening method, and inhibit the enzyme activity of traditional Chinese medicine (TCM) was established for the first time and mass spectrometry method for the determination of antioxidant ability at the same time. The establishment of affinity ultrafiltration mass spectrometry method, realized the active ingredients of traditional Chinese medicine (TCM) screening and structure characterization finish at the same time. This method for a single or different biological molecular targets, from traditional Chinese medicine resource in the screening of the active ingredient, helps to clarify many components, the mechanism of the multiple target effect of traditional Chinese medicine (TCM). In addition, the researchers will esi-ms were successfully used in the flavonoids and double chain, chain of DNA interaction research, found that the compound structure and DNA with the close relationship between the ability.

        In terms of quality control and evaluation method of traditional Chinese medicine (TCM), they used chemical metrology method, the chromatography/mass spectrometry analysis data and activity determination results of organic combine, constructs the scientific and effective traditional Chinese medicine integrated quality control and evaluation methods. This method not only strong characteristic, can realize quantitative, main components and is easy to identify, quick, convenient, etc. At the same time, this method is successfully used in varieties of traditional Chinese medicine identification, variety selection, origin, growth period, processing, compatibility mechanism research, etc.

        On Chinese native medicine ingredient structure characterization method of the study, the researchers set up inside the laser strengthening source of cracking (LEISD) new methods and successful used in neutral sugar and confirm the structure of the isomers. New method can not only determine the connection site of sugar, but also provide a -, - the configuration. They also found for the first time has the advantages of high sensitivity and good salt resistance of the sugar analysis of new matrix.

        It is reported that related to the project by a number of national natural science foundation, national science and technology support plan and focus on the development of science and technology plan projects of jilin province. During the project implementation, has published 91 papers, including 62 by SCI article; 25 for invention patents, of which 18 have been patent certificate; Cultivate postgraduate 15, Dr. 10. The project also won the 2012 jilin province scientific and technological progress first prize.

        "Proceedings" (version 4) 2013-01-02