To human ontology agent dosage strategy

China's traditional Chinese medicine to

        Editor's note: in the medical disease besides attaches great importance to the principle, method, square, medicine, attach more importance to dose, and so the ancient traditional Chinese medicine is not the secret lies in the quantity of the said, that amount is to determine the key factors of therapeutic effect. For years, professor of Chinese academy of sciences hospital gate 8, xiao Lin led the dose effect relationship research, he and his team from multi-angle in-depth to explore the relationship between dosage and effect of the formulas, the clinical curative effect is largest when the best dose for implementation. This edition is a special column introduces the ideas and research results of its party dose effect, in order to uncover "quantity" and "effect" between the mass of the secret.

        Syndrome differentiation and treatment, it is the essence of Chinese medicine theory. Principle, method, square, medicine, also is the core of treatment based on syndrome differentiation. In principle, method, square, medicine was determined, what are key determinants of curative effect? The amount! So the ancient traditional Chinese medicine is not preach the secret lies in the quantity of the said, or yue: preach the medicine does not transfer rate. Syndrome differentiation and treatment of past research, mainly concentrated in principle, method, square, medicine, and the study of quantity is less. And over the decades, differentiation, and modest results, especially acute and dangerous, heavy and difficult, often feel overwhelmed. This is also lots of doctor of traditional Chinese medicine itself. We say, therefore, treatment based on syndrome differentiation, in principle, method, square, medicine, must add a word: the amount! The principle, method, square, medicine, and quantity.

        Without a certain amount, there is no certain mass, there would be no effect. Shipment of quantity control ability, is the important measure of a doctor of clinical level, can grasp in a of the disease and syndrome, disease, accurate and precise dosage, is a doctor a sign of maturity. Healing is an art, is the way in treating method, show the creativity and effectiveness, is the breakthrough of excellence. And consumption strategy is the concentrated reflection of art therapy.

        Clinically, often see some doctors, no matter what disease, regardless of weight, length of disease, herb tea has always been to the end, the ingredients of prescription, are their taste and dose, are 10 ~ 15 g, two Fried, all points in the morning and evening. Little imagine, the soup too, pill is slow, also the soup, soup, the pill, pill, powder, plaster, Dan), pills, can pack? Has the size, critical, short-range application, curative effect first, fewer but better, medicine only leehom, appropriate is used "jing fang", regulate prevention, long-term use, safety first, appropriate is used "wai", his ingredients no difference? Drug points, with the doctrine of the toxic nontoxic, big small poison, poison dosage can close? Acute disease fast break, the first agent, a number of the suit, known as degrees, slow disease eat, day two clothes, cumulative effect, can obey the uniform? Visible, clinical with soup with pills, ingredients with multi-purpose oligonucleotides, small dose with use, taking several times a day, about quantity, also all about effect, greatly exquisite.

        Compared with the concentration-response relationship research of western medicine, the dose effect relationship research, is a huge problem. It is not only to the scientific level of dose threshold, also must study the philosophy and art level with the volume; It involves the existing medical norms, pharmacopoeia law, also involving the traditional custom. Reasonable dosage, calls for the joint efforts of the broad masses of medical workers and multidisciplinary, need a lot of doctors in practice and actively explore a broad range of clinical departments. It is worth mentioning: on critical patients of the rescue, can break through the "China pharmacopoeia" dose, play to the doctor's subjective initiative, due to illness, due to the certificate, because of the potential, because of person, from place to place, because, according to the utility, efficacy first, rather than to preserve our sanity, but beg without. This medical system, the legal issues involved, it is a very big and very worthy of study.

        Dose effect relationship research, is a new field, there are too many too many problems need to be solved, it will open a door, Windows, uncovered the secret of curative effect; It will enrich the connotation of syndrome differentiation and treatment, the bridge between science and philosophy, art; It will become a new subject for medical and pharmacy, traditional Chinese medicine and western medicine, basic and clinical and multidisciplinary cooperation, build a platform; It will lead the traditional Chinese medicine, to quantify era.

        At present, the effects of the formulas of traditional Chinese medicine research and dose of heritage, there are many misunderstandings, chaos and confusion. Dose the formulas research insufficiency, hinder the improvement of the curative effect of traditional Chinese medicine, the dose effect relationship research has become the key issues in traditional Chinese medicine.

        Specifically, "ingredients matter, component is more important. Dose changes of the formulas are very complicated, traditional Chinese medicine clinical sent the medicine has obvious dose gradient - mastery of clinical dosage with a formula, different doctors may exist bigger difference; Even same doctor applications in different situations the same prescription doses will also vary. Visible, clinical there are dominated by experience "in the strategy", namely "people-oriented ontology" the dosage of the strategy.

        Baidu encyclopedia on the definition of the word "strategy" : strategy is to achieve a goal, according to the possible problems in advance, make some corresponding solutions, and, in the process of achieving this, according to the situation development and change, to develop a new solution; Or according to the situation of the development and change, select the corresponding solution, ultimately achieve the initial goal. According to the definition of "strategy", we believe that "people the dosage of the ontology strategy", also can be called "strategy" with the quantity, is a doctor of patients, disease and illness after the accurate judgment, given the amount of countermeasures, namely after the determine of the formulas, decision or adjust the prescription of each flavour to the dosage and ratio between used dose of the drug, so in the security under the premise of get the fastest, the best curative effect. Use strategy is an important part of clinical dose theory, also consider doctors clinical level of important standard. When differentiation, choose, medication is determined, reasonable consumption is the key to curative effect. Concentration-response relationship research efforts will ultimately translate into can be used to guide clinical usage strategies, namely the safest, most effective clinical dosage.

        Accurate, based on medicinal materials quality has the guarantee under the premise of disease and syndrome, square, medicine is the most important factors that affect consumption. Amount, therefore, we believe that "due to illness, because of the quantity, because of the medicine amount, because of the party" is the most basic clinical usage policy.

        Use the formulas strategy

        1. The amount due to illness was

        Disease, refers to the kinds of diseases, and even more. : "with the disease" and "quantity" for potential. With disease refers to in the treatment of different diseases, the dosage of the drug may be different. Such as rhizoma coptidis modulation spleen and stomach disease, usually use 1.5 g to 9 g is enough, its purpose is not their clear heat, but drug compatibility with him to collect sheen open bitter drop, with su leaf rhizoma coptidis decoction treatment ou evil as an example, the dosage of rhizoma coptidis is about 1 g; And rhizoma coptidis diabetes, generally use 45 grams, 15 grams to specifically take its functions of discharge heat detoxification. Because of potential applied amount determined according to the priorities of the even more drug dosage. Generally even more urgent, the dosage should be bigger; Are you slow, light condition, consumption should be small. JuTong wu said "incurable diseases such as, and internal injuries, such as phase", critical illnesses, to prevent immediately is mutation, so the expectations, the key is to turn even more rapidly, a LLC, between the two agents in the hope of survival consumption tend to be big, in order to pick up the slack. Shaoyin disease three nasty under, with four two, hopu half a catty, rhubarb mirabilite triad urgent to save Yin, prevent and dried up. His illness is gentle, is relatively stable, or even a long time didn't change, so the amount can be gentle, slow and gradually close in their work.

        Heald above, "due to illness" strategy can be summed up as the long-term control of chronic diseases, energizer, light light of disease, good and evil, or pathogenic factors is light shallow, small dose of medication can receive four two dial one thousand jins effect, treatment of such diseases dose should be small; And critical care, chronic disease, pathogenic factors, severe disease, generally the evil reality is filled or vital qi deficiency, so the dose should be big, is the so-called to weight status, a small amount is a drop in the ocean, will not help.

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