The dose of medicine "as" law

- for the treatment of Chinese medicine and compound dose threshold, window of the building and thinking

China's traditional Chinese medicine to

        Traditional Chinese medicine (TCM) is the excellent management laws of TCM medicine in four important link directly to the clinical curative effect is the key link, including the determination of the choice of ingredients and dosage. Long most of traditional Chinese medicine emphasizes the accuracy of ingredients selection, in favor of treatment based on syndrome differentiation of traditional Chinese medicine literature in huge theory, tend to ignore the specific determination of doses. Indeed the choice of ingredients like targeted direction, it is important, but the dosage of the precision, such as for targeted distance judgment, has decided to shoot a target strength and skills. Perhaps this is traditional Chinese medicine compound, especially the classical square, though mostly after one thousand years of clinical validation, clinical curative effect, but it is difficult to clear. Many physicians in the practice for several years, finally found out the problem, in groping forward to lament: traditional Chinese medicine does not pass the secret in dose; Ingredients essential component is more important; Anything can be up and down, also about efficacy. Therefore, the traditional Chinese medicine and traditional Chinese medicine (TCM) compound dose range and specification, concentration-response relationship problem is the problem to be solved.

        The characteristics of the dose effect relationship

        Any drug are concentration-response relationship, there is a traditional Chinese medicine and traditional Chinese medicine compound concentration-response relationship has its own particularity. In fact every taste traditional Chinese medicine (TCM) contains a number of different components, at the molecular level is the equivalent of a small Chinese medicine compound. That a single taste traditional Chinese medicine (TCM) as a small Chinese medicine compound in the form of a complete individual as a unit involved in the composition of traditional Chinese medicine compound. And dosage of Chinese traditional medicine prescription only approximate or relative accurate, except a few toxic drugs, dosage of Chinese traditional medicine prescription is not very accurate, and the dosage range is bigger, it also makes the traditional Chinese medicine (TCM) and its compound concentration-response relationship is uncertain. Single specific due to its composition and chemical drugs, so it is more accurate therapeutic window, relatively clear concentration-response curve relationship. Chemical drug therapeutic window refers to the so-called generation treatment effect between the minimum concentration and the minimum concentration of toxic a reasonable treatment area (or called the scope of treatment). Ideal treatment is to maintain drug plasma concentration within the therapeutic window.

        The concentration-response relationship of traditional Chinese medicine and its compound compared with chemical medicine accurate concentration-response relationship, its own characteristic had decided the fuzziness and complexity of the concentration-response relationship, and because the cannot be used to describe the linear relationship between the chemical drugs, increasing the difficulty of study concentration-response relationship, such as a lot of experiments on Chinese medicine research results show that within a certain range, dosage and curative effect is higher than, namely with the increase of dose, efficacy by the result of the increase. But studies have found that part of traditional Chinese medicine compound although do exist with the increase of dose, incremental change law of utility increases, but after the dose, the utility does not increase with the increase of the dose. And, as a combination of single dose than change, the curative effect also different. Concentration-response relationship there is time, that is, sometimes a dose for a time, not necessarily effective in change, and dose the same time quantity is change, maybe will produce certain concentration-response relationship.

        Dose threshold, therapeutic window

        The necessity and its definition

        Is due to the traditional Chinese medicine and traditional Chinese medicine compound the fuzziness, complexity, which makes the concentration-response relationship not only of traditional Chinese medicine (TCM) and its compound through a curve, a chart, etc can explain. And because of its own characteristics, making the dose range, dose range of therapeutic window cannot be equated to chemical medicine and therapeutic window, and the form of traditional Chinese medicine (TCM) and its compound concentration-response relationship study of the important elements, also cannot use chemical drug dose and therapeutic window to clear the concept, therefore, for the treatment of Chinese medicine and compound dose range, the window defined as primary and necessary key.

        Through long-term clinical experience and in view of the concentration-response relationship in traditional Chinese medicine, we try to put forward the concept of traditional Chinese medicine (TCM) therapeutic window and dose threshold, trying to embody the basic characteristics of traditional Chinese medicine compound on dose.

        Dose refers to the prescriptions of traditional Chinese medicine (TCM) in place and the conditions of the corresponding doses, taken by the conditions of the different quantity is different, here also includes the syndrome differentiation and treatment of prescription thought in it, call it dose so, rather than simple medication. Prompt study dose must be aimed at indications to be meaningful. (Tong XiaoLin)

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