The influence factors of the dose effect relationship

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        The dose effect relationship has many influence factors, from the Angle of the medicinal herbs and yinpian, including the quality of medicinal materials, drug processing, etc.; From the point of the prescription, including the formulations and methods of decocting and taking medicine. The party dose effect study set up a chapter, decoction, and obey the formulas, for example, by topic and dose effect relationship with the readers to discuss the influencing factors and research methods.

        Decoction dose effect relationship between each other

        Xu Ling tire in the qing dynasty in the origin theory of medicine, said: "tisanes, most appropriate depth, the medicine effect not all care about this." Decoction of Chinese medicine, is not only the effective component of the dissolution process, and it is all sorts of physiologically active components in the drug chemical reaction, integration process.

        1. The Fried cooking utensils

        Chinese medicine decoction container with refractory casserole, POTS as well, can also use enamel ware or aluminium ware, stainless steel household utensils, because this kind of vessel has uniform thermal conductivity, stable chemical properties, slow cooling, the characteristics of chemical composition change is not easy to make drugs; Avoid iron, copper, tin and other metal container.

        2. Before the decoction soaking

        Avoiding most of the Chinese medicine yinpian for plants, has a certain size and thickness, should be placed inside the container before decoction soak in cold water, in order to make the surface moist, soft drugs, plant cell expansion, make the drug dissolution, effective ingredients to produce osmotic pressure and diffusion in the organization to tissue cells outside the water, at the same time can be avoided in heating decocting medicinal herbs in the organization when protein contained curing, starch gelatinization and affect drug active ingredient decoct, shadow and clinical effects.

        3. Water added decoction

        When TCM compound medicinal broth decoction plus how much water dissolution of effective components have very important significance. Studies have found that low doses of the decoction were significantly higher than the rate of dose, significantly higher than the high dose; Dose square fry out rate is significantly higher than that in high dose. Showed that frying take in certain circumstances, add how much water for the quality of the produced liquid has very significant effect.

        4. The decoction temperature

        Chinese traditional medicine decoction generally adopt the traditional direct fire heating method, its advantage is decoction temperature easy to control, the solution volume easy to master. Chinese medicine decoction, generally use the high heat or fire first solution fast boil, and then gently the small fire slowly decoction.

        5. Decoction time

        In traditional Chinese medicine compound one decoction decoction time is very important in the process, appropriate decoction time has important significance for improving drug clinical curative effect. Decoction time is too long, some of the ingredients was damaged or lost; Of drug ingredients decoction time insufficient, the dissolution.

        6. Decoction frequency

        When Chinese traditional medicine decoction medicine effective component first into medicine organization dissolved in the water, and then spread into the external solution, when the concentration of a solution of medicinal materials, both inside and outside equilibrium, because of osmotic balance and effective components will no longer continue to dissolution. It is generally believed that in order to make full use of the medicinal materials and avoid waste, better efficacy, decocting times more can make the drug active ingredient precipitate completely, but for some herbs, multiple decoction has destroyed the medicine effective component, has affected the clinical effect. So decoction frequency according to clinical need, should not be mechanical limit.

        7. The solution volume

        Take of traditional Chinese medicine decoction method for head and two Fried Fried merger blending of liquids, points 2 times sooner or later. Patients each dose of about 150 ~ 200 ml, this determines the traditional Chinese medicine finally frying take quantity about 400 ml, if the patient is difficult to completely take can cause waste, affect curative effect. Explore a kind of effective balance between water added with Fried take quantity, precipitation is to address the drug active ingredient and the surest way to patients taking the contradiction. Therefore, fry out of liquid concentration is extraction of traditional Chinese medicine decoction fluid is the important way of excess water.

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