Children's proprietary Chinese medicine adverse reaction chaos research is urgently needed

The food industry network

        At last Saturday's first QiHuang BBS, traditional Chinese medicine experts reached a consensus: "children in traditional Chinese medicine (TCM) is an indispensable main force, that cannot be neglected among traditional Chinese medicine (TCM) industry. Large scale of more than five hundred million strategic products will be more and more." Start the study of toxicity and adverse reactions of proprietary Chinese medicines to children so it is urgent to study.

        Zhang Shichen, vice chairman of China association of traditional Chinese medicine, told reporters that the children's proprietary Chinese medicines more chaos, mainly is the three big factors hindered the children's development of Chinese medicine.

        One is attending most pediatric medicine product instruction clinical application function positioning is not clear.

        2 it is to turn adult academy products lack of children proper usage and dosage and adverse reactions of warning. "Indicates a grownup children, children's medicines indicates a reduction of adult medicine." Chinese academy of engineering Li Lianda pointed out.

        Three is the most product manuals are still stay in "adverse reactions, the use of taboo, etc. It is not clear". Children's growth and development, the function is not perfect, children's medicines process in the body, absorption and utilization, decomposition, metabolism, discharge, pharmacokinetic, etc, is different from adults. Drug side effects and adverse reactions of children and adults is not all the same, but cause deafness caused by deaf mute, and the influence of the blood, liver, kidney function than adults. Therefore, children's drugs dosage form, specification need special consideration.

        Toxicity measurement mark unclear proprietary Chinese medicine herbs research is urgently needed

        Experts Song Minxian introduced Chinese medicine, pediatric proprietary Chinese medicine contain toxic Chinese medicines, medicinal herbs of a total of 130, accounting for 34.75% of the total number of varieties; Contains two or more than 2 smell of toxic Chinese medicines, medicinal herbs of a total of 59, the proportion is 15.77%.

        And the reporter understands, there is no prescription drug and dose, or cannot be calculated according to the pharmaceutical standards of each preparation unit (e.g., per piece, g, etc.) dose on proprietary Chinese medicine accounted for one-third of the total. Doses not indicated ages varieties also accounted for a third, and age is no law at all.

        "The key is that children of proprietary Chinese medicine contain toxic drug adverse reaction is now also said not clear." The first affiliated hospital of tianjin medical university, dean of Ma Rong told reporters. "We should optimize the older drugs prescription, removing cinnabar content higher drug. Such as tongrentang's wang bao red powder and seven Jane pills." Prudent use of toxic herbs, he argues, should cause the attention of children as people, children toxic Chinese medicines, traditional Chinese medicine research is urgent.

        Children's drugs have development opportunities is central to the development of adverse reaction

        "The doctor walked at the edge of the unauthorized practice of law -- over 50% of children's drugs." Wang Junhong said, director of the Beijing university of Chinese medicine dongzhimen hospital of pediatrics, the causes of these conditions are, companies don't pay attention to children's drugs research and development; Children's drugs market is not stable, manufacturers are reluctant to cut investment.

        And because of ethical issues, researchers recruited children clinical trials was very difficult. Children's medicines test experience insufficiency, high incidence of adverse drug reactions. In our country, in 2006 to participate in the national D R A monitoring report related data, the hospital for sick children in children was 12.9%, and the incidence of drug adverse reaction of newborns was 24.4%, only 6.9% of the adults.

        However, the state drug administration began to support the development of generic drugs for children, children's drugs currently still have the opportunity of development, drug companies can act in four aspects: one is to develop suitable for different age children use the types and specifications of drugs; Second, the innovation medicine declaration declaration along with all the children's types and specifications; Three is to develop targeted at children special disease, rare disease research innovation; Four is to apply for generics children with specifications and formulations.

        Li Lianda thinks, adverse reaction is the emphasis of future research and development of proprietary Chinese medicine pediatrics. In addition, still can include, children's special disease, special drug research and development; Children's common diseases, frequently-occurring disease, selects the children's characteristics of new drug research and older drugs secondary research; Children's medication dose, frequency, course of study; Children's medication safety research, common side effects, has important influence on growth and long-term prognosis of side effects and complications, such as the prevention and treatment research.

The original link: http://www.foodqs.cn/news/tbgz01/20137515913227.htm

(in the site editor)