With the modern science and technology reveal Chinese medicine compatibility taboo 
 
 
Yu jing ying Chen Hu ZhuangYingNa
 
 
January 17, 2014
 
 
 
Source: People's Daily overseas edition 
 
 
 
 
 
 
 
The scientific research team in the monthly work
Jiang Xijuan perturbation 

        In traditional Chinese medicine with modern preparation has been increasingly widely used at present, the form of occurrence of adverse reactions happen from time to time, make a lot of people are worried, more make foreign some people talk about traditional Chinese medicine (TCM). How to make the western understanding of the connotation of TCM theory system, and to accept and use of traditional Chinese medicine (TCM), is a very difficult job. Safety evaluation of traditional Chinese medicine (TCM) this bottleneck, restricted the Chinese medicine modernization and internationalization. At present, in our country under the unremitting efforts of scientific research personnel and getting the fundamental change in the situation. 
 
        Research achievements won the national first prize 
 
        By the Chinese military academy of medical sciences, the research team, led by researcher monthly, absorb and use of systems biology, bioinformatics, analytical chemistry, such as modern science and technology, lasted more than ten years of hard research, a breakthrough in the field of traditional Chinese medicine (TCM) security key technology. Project team created the toxicity of traditional Chinese medicine (TCM) early prediction, analysis of toxic substances and compatibility taboo to evaluate three kinds of technologies such as the eight methods, and use the integrated technology platform, to clinical prone to adverse reactions to the safety of the seven major types of Chinese medicine system research, clarified the mechanism of compatibility of traditional Chinese medicine theory of modern biology, the empirical "18", not compatibility, licorice "reconcile the medicine" and so on the classical theory of TCM. By military academy of medical sciences, zhejiang university, the people's liberation army general hospital, tianjin university of Chinese medicine, China academy of traditional Chinese medicine, biological technology co., LTD. Shenzhen micro core and seven units of henan institute of scientific research personnel of project team, also won the 2013 annual national scientific and technological progress first prize. 
 
        Empirical herbal classic theory of modern science and technology 
 
        Why can licorice "reconcile the medicine"? Ginseng, hellebore why are "Nemesis"? Why decoction prescriptions have order, time, and many other pay attention to? 
 
        People participate in the hellebore, for example, researchers first studied the two "not to make" material basis. Hellebore toxic ingredients are mainly veratrine represented by a variety of alkaloids, when people participate in the hellebore close Fried, these toxic alkaloid dissolution increases, and the efficacy of useful components such as ginseng saponin dissolution is reduced. When using the ratio of different drugs, decocting methods and time, toxic ingredients precipitation change will happen. Therefore, change the compatibility proportion, decocting methods and time, has important influence on effectiveness. The researchers also further from the level of molecular biology reveals how these alkaloids produce toxic effects to the human body. 
 
        The complexity in the process of the research of Chinese traditional medicine also got fully verified. The study found that a small amount of ginseng can aggravate hellebore biased, make its toxicity obviously enhanced, excessive compatibility, then you can hide hellebore biased, its toxicity. More magical is, when people participate in hellebore to specific proportion compatibility, toxicity was completely disappear. It seems, and not against, and with, is not absolute, whether this is what the secrets of the Chinese emphasize dialectical administer? 
 
        System research for modern traditional Chinese medicine (TCM) radically 
 
        Why traditional Chinese medicine injections can cause adverse reactions? Taking compound medicines containing cinnabar and realgar, toxic mercury and arsenic will gather in the body? 
 
        TCM injections as a key initiative for traditional Chinese medicine has made great contribution to the development of innovation, but also because of the serious adverse reactions, become "Waterloo" traditional Chinese medicine modernization. In h. cordata injection, for example, because of its unique antibacterial effect, once popular new "SARS" in 2003. But as a result of continuous serious adverse reaction, in 2006, by the relevant departments of the emergency stop. 
 
        China academy of traditional Chinese medicine Liang Aihua led the research team focus on research of this subject. They found that h. cordata, pulse and other 10 kinds of injection allergic characteristics different from true allergic reaction, for "kind of allergic reaction," that is not because the body's immune antibody formation allergic reaction, but due to the stimulation of the drug itself, if it can be reasonable control dose, to reduce the infusion speed, can reduce the incidence of adverse reactions. Their research found that sensitization of herba houttuyniae injection material is a kind of used to promote the dissolution of active ingredients and absorption of solvent, and find the ideal alternative. 
 
        Many contain toxic elements in traditional Chinese medicinal materials, such as the realgar, cinnabar contains toxic heavy metals arsenic and mercury. For this class of drugs, the international general evaluation based on total arsenic, mercury, realgar, cinnabar, toxicity, the drug is disabled list. The medical profession in our country think this way is not scientific, but couldn't get the scientific evidence. For similar reasons, the United States, Canada, European Union and other blacklisted 70 kinds of traditional Chinese medicine (TCM). The lack of scientific evaluation method to be a key issue in the influence of traditional Chinese medicine trade. 
 
        To dissolve the misunderstanding and prejudice, the project team by studying the realgar within organs after drug distribution and accumulation characteristics of organic and inorganic arsenic arsenic, realgar found arsenic in the blood distribution and accumulation is the highest, reveals the possible mechanism for the treatment of leukemia. In addition, the toxicity of inorganic arsenic in the body in the realgar can quickly turn into dimethyl arsenic toxicity is low. Researchers to further study the relationship between the amount, when, poison, for reasonable usage and dosage of realgar time provides a scientific basis. At the same time, the researchers also illustrates the distribution and accumulation regularity of soluble mercury in human body. 
 
        Integrated platform for improving the efficiency of drug development 
 
        Which sorts of compounds can lower cholesterol? Which can protect liver? Several kinds of ingredients and medicine will produce toxic? 
 
        To effectively overcome coordinating diverse, complex such as traditional Chinese medicine toxicology effect comprehensive, toxicity mechanism security research, the key technical problems in the project team in the national natural science foundation of China, with the support of a number of topics set up Chinese medicine characteristics of early warning, analysis, evaluation method and key technology. 
 
        Aimed at the problem of early toxicity prediction technology, zhejiang university Fan Xiaohui team adopt relevant toxicology genomics technology, drug toxicity prediction in advance to the genetic level stage. In layman's terms, is in the body physiological index has not changed, can be found that the drug toxicity caused by genetic changes, thus greatly improving the toxicity of traditional Chinese medicine (TCM) early warning capability. This is equivalent to in the case of you are not fat, forecast the body already overnutrition, remind you to pay attention to eating. 
 
        Project team on the basis of a number of advanced technology to build the Chinese traditional medicine toxic potential targets, drug hepatotoxicity, all toxic traditional Chinese medicine (TCM) and Chinese pharmacopoeia of the underlying database related database content integration with the United States, Japan, is by far the most comprehensive, the most toxic traditional Chinese medicines of the system database. 
 
        This is a comprehensive technology platform directly contributed to the 103 new drug research and development process. For multiple the efficacy of Chinese herbal compound and single parts and components, screening natural compounds found can effectively reduce the cholesterol, also developed with liver injury protection function of new drug "beauty GanLe", and the successful listing. The "red yi capsule" to become the first in view of the plateau hypoxia caused by fatigue syndrome drugs, in wenchuan, yushu earthquake relief, the Antarctic polar exploration, its application in the special environment, such as the astronaut training.