From the perspective of the antiviral drug suggests the new connotation of traditional Chinese medicine 
 
 
Release date: 2014-11-06 01:31:30 
 
 
Source: journal of science and technology 

    Innovation of revelation
 
    In recent years, with some Chinese medicine and compound material foundation of the traditional Chinese medicine (TCM) have been elucidated, Chinese traditional medicine curative effect by the modern clinical research confirmed, especially in the prevention and control of some viral diseases, tumor, diabetes complications and senile disease showed certain advantages, research and industrialization of traditional Chinese medicine (TCM) has been more and more get the attention of medicine.
 
    However, due to the traditional Chinese medicine (TCM) and its compound composition is complicated, and most of the efficacy of traditional Chinese medicine (TCM) mechanism has not been scientifically proven, there is still not widely accepted by the international mainstream medicine system. How to adapt to the development of modern medicine, combined with the traditional experience and traditional Chinese medicine (TCM) modernization of the existing research results, the use of advanced technology, to establish effective mode of modernization of traditional Chinese medicine research and development, to promote scientific, modernization and internationalization of Chinese medicine, promote the curative effect of TCM products to become an international drug, has become an important subject of traditional Chinese medicine scientific research workers. Hong-xi xu professor of Shanghai university of TCM through more than 20 years of research and practice, explain the mechanism of Chinese medicine medicinal material and pharmacological activities have done a lot of exploratory work, made gratifying progress and achievements, and relevant research results in the international well-known drug research academic journals published more than a higher rate of reference of research, also applied for a patent for invention, a number of American research made greater contribution to promote the Chinese medicine scientific and modernized.
 
    Love of traditional Chinese medicine (TCM) study of more than 20 years
 
    For more than 20 years, hong-xi xu successively in Japan, Singapore, Canada and Hong Kong well-known academic institutions, long engaged in the study of traditional Chinese medicine efficacy evaluation, new drug research and development, and project achievements of intellectual property work, the leadership team and partners in multiple international academic journals published more than 200 SCI research papers, relevant results to successfully apply for six U.S. patents and 1 PCT patent. For years, professor xu in clarifying mechanism of Chinese medicine medicinal material and pharmacological activities of research work and achievements, recognised by the domestic and foreign counterparts, has more than 40 invited to the United States, Britain, Austria, Australia, Japan, South Korea, Brazil, Singapore, Canada and Hong Kong, Macao and Taiwan to participate in international academic conferences, such as conference report, introduction of traditional Chinese medicine research. Prof xu head of the world association of traditional Chinese Medicine association professional committee of the Chinese traditional Medicine Analysis, vice President of, the intermediate professional committee of the Chinese Medicine identification, vice President of international modernization of traditional Chinese Medicine, academic conference, chairman of the joint chiefs of staff, English magazines Chinese Medicine deputy editor, Phytochemical Analysis and so on more than 10 domestic and international professional magazine editors, and academic institutions more than Hong Kong, macau, Taiwan and the visiting professor and academic consultant.
 
    Promote Chinese medicine industrialization of research results
 
    Hong-xi xu in his early years studying in Japan, the key to carry out the Antiviral medicine research, he has hundreds kinds of traditional Chinese medicine for the Antiviral activity screening, the study on the Antiviral magazine "Antiviral research", the first reported 146 kinds of traditional Chinese medicine (TCM) activity in vitro against a variety of virus of research results, proved that 12 kinds of Chinese medicine on herpes virus infection of experimental animals has obvious curative effect. At the national university of Singapore and Canada Dalhousie university to further my study, during hong-xi xu continue to conduct the thorough research to the antiviral medicine, and first isolated from folk herbs big grass with anti-hiv activity of new triterpene composition, his first patent inventor success will be the results of application in the United States for a patent for invention, and authorized; Since then, he again found significant resistance from the Chinese traditional medicine selfheal herpes virus activity of polysaccharide component, the study has been successfully transferred to pharmaceutical companies in the United States and Canada.
 
    Traditional Chinese medicine (TCM) standard is the necessary tools for identification of traditional Chinese medicine and its authenticity and product quality. Hong-xi xu team created gambogic acid which was prepared by high speed countercurrent chromatography, astragalus saponin I, II, great li le acid and other chemical reference substance, completed the chemical reference substance 400 kinds of Chinese medicine, including 265 kinds of products sales to the United States, Japan, France and South Korea and other countries and regions. In 2008, professor xu as the corresponding author in SCI journal "Chinese Medicine", a paper published on the Chemical markers for quality control of herbal medicines ", traditional Chinese Medicine (TCM) Chemical reference substance system including the selection, analysis, and applications in traditional Chinese Medicine quality control strategy. The paper has since published by scholars from all over the world to download more than 27200 times, all of the papers in the magazine ranked highest reference record in the top 5, has a larger academic influence.
 
    In 2011, professor hong-xi xu was selected after the "one thousand plan" national distinguished professor, full-time as a professor at the university of Chinese medicine in Shanghai set up the innovation of laboratory medicine and traditional Chinese medicine drugs Shanghai engineering research center of colleges and universities, to lead the team to carry out the antiviral and anticancer mechanism, pharmacology of Chinese medicine is committed to clarify antiviral and anticancer effect of traditional Chinese medicine material base, reveal the effect mechanism, strong found activity, low toxicity and high selectivity of lead compounds. At the same time, also established the molecules, cells and animal antitumor drug screening and evaluation of the level of research platform, focus on chinese-made garcinia PPAPs with antitumor activity in class and to identify the components of xanthones class and its mechanism of action research. , hong-xi xu's research team has research value to 15 kinds of garcinia carried out systematically and in-depth research work and success in the more than 200 compounds, and identified more than 90 new structure and display a variety of pharmacological activities of compounds, especially from yunnan gambogic (g. yunnanensis) isolated from the active compounds of Guttiferone K and Oblongifolin C, has the special antitumor activity, study confirms that they can inhibit cell proliferation, promote apoptosis and inhibit tumor cell autophagy mechanism, regulation and tumor occurrence, development, metastasis and recurrence of related signal pathways that produce antitumor activity, have very good development prospects. After many years of hard work and accumulation, professor hong-xi xu led the team and partners in China to produce active ingredients and pharmacological mechanism of garcinia convenient research has achieved fruitful results, successively in "Autophagy" and so on international famous academic journals published more than 40 content related SCI research papers, and applied for more than ten American and Chinese invention patents. Nearly three years, professor hong-xi xu's team has won seven national natural science fund projects and projects two major national drug discovery. By strengthening basic research and practical, high level academic papers published, and apply for international patent, in order to clarify the material basis and the therapeutic effects of traditional Chinese medicine (TCM) mechanism, enhance the scientific nature and the international influence of Chinese medicine, promote the transfer and industrialization of traditional Chinese medicine (TCM) results, the real service for the industry to provide technical support.
 
    Dream is not afraid of hard
 
    Hong-xi xu told the journal of science and technology, the way of the pursuit of dreams is not plain sailing, especially scientific research often are often faced with the bottleneck problem. Early Sim KY, director of the chemistry professor at the national university of Singapore, under the guidance of his postdoctoral research hong-xi xu, to search for antiviral active ingredients from medicinal plants.
 
    Screen display with early antiviral activity at the beginning of the study of several medicinal plants are commonly used Chinese herbal medicine, there have been more studies on chemical composition, indicates the possibility of new compounds found from it is small, the results of novelty will be discounted. Hong-xi xu was not discouraged and give up, but a careful reading of existing literature, summarized which have been found and reported compounds, breach. Everything comes to him who waits, after efforts to study and practice, finally from Japan adina, ginger mountain belong to have discovered a new active compounds in plants. Relevant achievements not only successfully applied for patent in the United States, but also in the international famous academic journals.
 
    As the field of traditional Chinese medicine "one thousand plan" in the middle of the few countries distinguished professor, hong-xi xu shoulders the mission of inheriting carry forward the traditional Chinese medicine, he is convinced that with scientific, modernization, industrialization and international goal, unremitting exploration and discovery, can make the ancient TCM to glow the new vitality, better for the health and well-being of mankind.