Dose effect rule and reasonable dosage strategy 
 
 
Lin-hua zhao Lian Feng mei He Lisha China academy of traditional Chinese medicine hospital of the gate 
 
 
China's traditional Chinese medicine to 

    Preventive medicine, slow disease control, the party ambiguities (1 ~ 3 g applications.
 
    To treat diseases in general, the party 1 ambiguous (3 ~ 6 g applications.
 
    Treatment of critical patients, the party 1 ambiguities (6 ~ 9 grams of application.
 
    Involved by the side of the highly toxic drugs, should consult pharmacopoeia.
 
    Curative effect is the life of the TCM, syndrome differentiation is the essence of TCM. When differentiation, choose, medication is determined, reasonable dosage and becomes the key to improve the clinical curative effect. "The principle, method, square, medicine" as the four key elements of traditional syndrome differentiation and treatment system, and the question of "quantity" is the lack of system theory in this paper.
 
    Clinical dosage strategy refers to the doctor for maximum effect, the process of selecting the optimum dosage range. Use strategy is an important part of clinical dosage theory, also consider the doctor clinical level of important standard. Medical sage zhang zhongjing "typhoid miscellaneous disease theory" fewer but better, the formulas of medicine leehom, known as "the parties", is a classic of square represents all previous dynasties Chinese medicine. But for long time, weights and measures of variation, make of zhongjing the party cause dose riddle - about how the party 1 two conversion, there are dozens of answers.
 
    Beijing university of Chinese medicine professor Fu Yanling team through literatures and approved by party drug weight measurement, the party principle decoction extract, clinical effectiveness and safety of the formulas and a series of research, finally research by party 1 two approximately equal to 13.8 grams.
 
    After the party source dose in clinical application can directly convert? How to a broader range of looking for clues in reasonable amount? 973 plan "is given priority to with quantity - effect relationship of classic parties related basic research" project team in China, the traditional Chinese medicine academy of sciences hospital gate 8, under the guidance of professor xiao Lin, taking the system research of this problem.
 
    Study with puerariae and scutellariae and coptidis decoction
 
    From treatise on febrile disease, with puerariae and scutellariae and coptidis decoction of radix puerariae, radix scutellariae, rhizoma coptidis, radix glycyrrhizae four herbs, is the association of treatment of intestinal hot and humid heat under the classical prescriptions. Clinical experience and research at the early stage of the team found that has a definite hypoglycemic effect with puerariae and scutellariae and coptidis decoction. So in the 973 plan to treat type 2 diabetes with puerariae and scutellariae and coptidis decoction (intestinal humid certificate) as one of the demonstration, to carry out the party dose effect relationship research, explore the law of dose effect.
 
    Team to evidence-based medical research as the core, carried out at the beginning of the whole party with puerariae and scutellariae and coptidis decoction treatment of type 2 diabetes multicenter, randomized, double-blind, dose of parallel controlled clinical study. Low dose group on the basis of modern teaching material 1 2 or 3 g design, press 1 dose group two (9 g, high dose group 1 two 15 grams. The results show that the effective soup can reduce fasting blood glucose, and glycosylated hemoglobin, and has a dose dependent.
 
    Jiangxi university of traditional Chinese medicine team through different doses according soup intervention high-fat joint chain urea with cephalosporins diabetic rats model, confirm with lowering blood sugar, glycosylated serum protein with puerariae and scutellariae and coptidis decoction. Clinical and experimental study confirmed that the whole party together with concentration-response relationship between dose and effect.
 
    Team through the treatise on febrile disease origin decoction method and modern decoction method of comparative study, found that modern decoction method can improve the effective ingredient dissolution, more save medicine. From the effectiveness, safety and save medicine comprehensive consideration, recommended by party 1 or 9 grams of best.
 
    Along with the disease on jun
 
    Team to for demonstration with puerariae and scutellariae and coptidis decoction, the establishment of the science to reveal the new available gentleman medicine method.
 
 
 
Unfinished, full text links: http://www.cntcmvideo.com/zgzyyb/html/2015-06/26/content_100628.htm