Doctors in Shanghai found after the traditional Chinese medicine decoction "small gene", or to turn off the disease genes

Time: 2015-10-29

Source: surging news

Author: Jiang Lijun

Traditional Chinese medicine (TCM) after decoction in addition to the chemical composition, which entered the body and what? Combine traditional Chinese and western medicine hospital affiliated to Shanghai university of TCM pediatrics experts chao-bin shen group through the study found that after the decoction of traditional Chinese medicine, still exist a lot of small RNA molecules, these tiny RNA plays an important role in gene regulation, can provide theoretical basis for traditional Chinese medicine cure, can even verify ancient Chinese say "eat what repair what". On October 27, chao-bin shen group announced the results to the media.

Why more than 700 years of ancient medicine useful? Medical experts debate

"Good good study yupinfeng this classic by the parties, the formula has been used in China for over 700 years, to the children's recurrent respiratory tract infections, pediatric sweating has good clinical curative effect, but as modern medicine, hopes to use scientific means to clarify the immune mechanism." Chao-bin shen told reporters, the surging news (www.thepaper.cn) 20 years ago, the famous Chinese pediatric immune expert professor should daming suggest such studies of him.

How does Chinese traditional medicine, there has been heated debate for many years. More than three years ago, chao-bin shen and natural medicine chemistry teaching and research section at the fudan university school of medicine, professor YuPeiZhong had a debate. YuPeiZhong thinks, after processing and decoction of traditional Chinese medicinal materials, chemical composition, is the most possible pharmacological efficacy and chao-bin shen disagree, he thinks that does not exclude the Chinese traditional medicine after dealing with the "small genetic material".

Chao-bin shen said "a little genetic material is" small RNA, which is a kind of can adjust the "small gene sequence of gene expression, its main function is to resist the gene transcription. In the medical sense, tiny RNA is a disease of biomarkers, and the means of gene therapy.

In 2012, nanjing university professor zhang and his team in Cell Research journal (22 (1), 2012) published a paper on small RNA (miRNA), plant some of the small RNA (miRNA, namely the miRNA) can enter human body through daily food intake means blood and tissues and organs, and then through the way of regulating the target gene expression in the human body affect the physiological function of human body. That is to say, from material of plant cells in transboundary impact even regulate the physiological functions of animals, a finding that has caused a heated debate in the international scientific community, still there are many different opinions.

Traditional Chinese medicine (TCM) after decoction, there are still a lot of "small gene"

In chao-bin shen and YuPeiZhong debate, professor of Shanghai jiaotong university school of medicine, immunity test to grind room dong-qing zhang acted as a "peacemaker" : "your own research from different direction, see the results." In the end, two people cooperation, YuPeiZhong provides drug research conditions, such as extraction experiment site and laboratory animals chao-bin shen took to jade screen small DNA extraction and separation results, prescriptions YuPeiZhong also extracted from prescriptions and special active chemical components.

Chao-bin shen said, considering the Chinese herbal medicine is characteristic of the genetic resources in China, in terms of understanding the principle of Chinese herbal medicine cure there is always the "say, above the" defect, so the subject focused on herbal medicine and regulating gene is associated with.

In animal experiments found that several times, yupinfeng indeed has the role of immune related gene expression regulation. Group to further explore yupinfeng powder of various kinds of small gene expression, it was found that Chinese traditional medicine after decoction, there are still a lot of "small" genes. Chao-bin shen called they can drink "gene therapy", he says, it provides a theoretical basis for the traditional Chinese medicine cure, prove yupinfeng powder is a kind of peculiar immune regulator.

"Dried medicinal herbs mummy look like plants, indeed it is hard to imagine that there are active ingredients." Chao-bin shen said that this is the most truly reveal that traditional Chinese medicine (TCM) after decoction is how to actually enter human body, and is absorbed by the human body can use of research methods, he explained that the DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) is the material basis for the gene, such as egg yolk (DNA) and egg white (RNA), enter human body can be absorbed by digestive decomposition, but small RNA into the human body is not digest, a vast majority of the situation can be directly absorbed small molecules, so want to be the change of natural treatment disease gene expression.

"Egg of DNA and RNA can't be used, only provide nutrition to the person, can't change of gene expression, but the main role of small RNA is the expression of resistance genes, mostly simple understanding should be a genetic" switch "in the" closed "." Chao-bin shen said.

"The ancient Chinese have a saying, that eat what repair what, the west also have the same words, is a 19th century German philosopher Bach says phil's 'We are what We eat." Chao-bin shen said that oneself and Zhang Chen in the professor's research results, or can provide this kind of simple materialism philosophy with a scientific interpretation.

Chao-bin shen group of the research results will be published in the journal of Chinese herbal medicine, the magazine is in the China science and technology periodical citation report "Chinese materia medica class first.