Improve the mechanism to help Chinese medicine made new again

Time: 2015-11-06

Source: China's traditional Chinese medicine

Author: zhang bl Zhang Junhua

, though the ancient traditional Chinese medicine, but the idea is not behind: the human and the nature harmonious nature, value idea, the viscera related overall treatment based on syndrome differentiation of individualized diagnosis and treatment, health care not cure disease of active preventive medicine thought, etc, all reveal the advanced nature of traditional Chinese medicine. The medical profession faces many challenges, train of thought and solution can be obtained from the medical. Of Chinese and western medicine and meaningless, seek to enhance the curative effect of disease prevention and control is the "right" between medical.

, we will not stick to one pattern to choose direction, selecting subject, support personnel, to perfect the market under the condition of the sports system, promote joint research, collaborative innovation, need to focus on personal subjective sex, advocating initiative, combine the role of the collective and individual well, more flexible and more diversified evaluation mechanism and incentive mechanism, mobilizing the enthusiasm and creativity of scientific research personnel, let more young people dedicate myself to the scientific research, promote the rapid development of science in China.

, people of Chinese medicine must be self-confidence, self-improvement, little debate, much practice, limited, ocean for convenient, open mind to accept more subject to join in the study of traditional Chinese medicine to protect good, good study, make good use of this great treasure house of Chinese medicine, let the ancient Chinese medicine made new again.

Tu researchers discovered artemisinin, effectively reduce the mortality rate of malaria patients, won the 2015 Nobel Prize in physiology or medicine. This is the first time domestic research results of Chinese scientists won the Nobel science prize, writing more than the first. Exciting news spread through the country, and praise, such as tide, also caused the depth of the interpretation and discussion, and even the debate.

The debate the truth, the debate to facilitate the formation of consensus. Tu, for example, is the discoverer of artemisinin, artesunate project success cannot leave the country under the system of the collaborative research, is China's scientists collective achievement; Ancient Chinese medicine with modern science and technology original achievements made binding energy, better benefit mankind; Can also help in scientific research system, evaluation system and personnel training and so on deep thinking, let the first Nobel Prize of medicine have more positive energy, promote more Chinese entrance into the Nobel research results. Artemisinin research won the Nobel Prize also brings many inspirations to debate and think.

Medical research should be on clinical significant demand

Fundamental purpose of medical research is to relieve pain, maintain health. The Nobel Prize in physiology or medicine for original innovation and the discovery of the most beneficial to human health. At present, the phenomenon of life and the understanding of the mechanisms of disease is relatively superficial background, medical research focus on the micro world of regression analysis, the result is limited, there is a great distance, transformation and application of results from clinical for solving the end of the clinical disease research. Nobel bring us enlightenment is, in the field of medical research more on clinical significant problem to research, to solve difficult problems, reduce mortality and improve the cure rate and patients' quality of life. The development of artemisinin, caught malaria prevention and control requirements, the multidisciplinary, multiple cooperating institutions of scientific research personnel, perseverance, the success. At present, acute infectious disease, tumor, cardio-cerebrovascular disease, diabetes, depression is a disease of the harm to human health. Reform is a worldwide problem, the medicine pattern transforming from disease to health medical medicine also has a lot of difficulties. Development must be guided by the clinical efficacy of new drugs, new drugs have curative effect, these are the urgent need to solve the problem.

Medical research "to go", is an urgent need to complementary advantages of Chinese and western medicine, contribute to tackle these problems. Artemisinin won Nobel Prize, however, that more than a century of Chinese and western medicine battle is heating up again: some people believe that the success of artemisinin won the Nobel Prize is the traditional Chinese medicine, also some people think it is the victory of the western medicine; Some recognize purified chemical composition new drugs from traditional Chinese medicine (TCM) is the correct way to traditional Chinese medicine (TCM) modernization, others think that this is a study of traditional Chinese medicine.

The doctor of traditional Chinese medicine and western medicine are not equal to science, but all have scientific composition, just different proportion. The progress of science is developing, that science does not necessarily tomorrow today or right, now is not the content of the scientific explanation is not necessarily is not correct. Belong to different systems of medicine of traditional Chinese medicine and western medicine, the phenomena of life have different understanding and disease development. But, disease, no distinction between Chinese and western and Chinese medicine and western medicine have a common purpose, is in order to maintain health and reduce disease, there is also a part of the same measure. Traditional Chinese medicine and western medicine there is no fundamental gap and have good complementarity. Traditional Chinese medicine although old, but the idea is not behind: the human and the nature harmonious nature, value idea, the viscera related overall treatment based on syndrome differentiation of individualized diagnosis and treatment, health care, cure not ill of active preventive medicine thought, etc, all reveal the advanced nature of traditional Chinese medicine. The medical profession faces many challenges, train of thought and solution can be obtained from the medical. Of Chinese and western medicine and meaningless, seek to enhance the curative effect of disease prevention and control is the "right" between medical.

Giving full play to the advantages of the system, pay attention to personal creation contribution

In the middle of the 20th century, when the condition of our country scientific research units and technological strength, only on one department, one unit is difficult to achieve significant scientific research projects. Under the condition of hard, scientists completed multiple scientific feat in China. "Rocket", the success of the project and so on artemisinin thanks to the group cooperation under the sports system. National "523" project team brought together more than 60 units of more than 500 scientific research personnel, they regardless of the fame and fortune, tenacious struggle, unity and cooperation, towards the same goal, collaborative research, make a breakthrough. Today, our country's economic strength and scientific research level and the technical force and equipment have changed, but the system under the joint research, collaborative innovation mode is not out of date, for to organize the implementation of major national scientific research project still has important practical significance.

"Scientific research is not to fight a battle", but the scientific evaluation of individuals in the group contribution to pay attention. Evaluation mechanism and method of science and technology in the larger differences in different countries or organizations, such as major achievements were made in the Nobel science prize is awarded to the first discoverers of, do not recognise the collective achievement, generally 1 to 3 people, and not more than two colleagues to share. Nobel award evaluation committee is the most important task is to choose candidates who made important discoveries, the evaluation process is often more than five years, experience different members of the committee of multiple evaluation still can pass the candidate is clearly recognized.

Lasker awards committee believe that researchers at tu was the first to bring artemisinin "523 project", the first extract with 100% inhibition rate of artemisinin, the first scientist to carry out research in the clinical evaluation, she is the first discovery of artemisinin. Also as Mr D., artemisinin is a lifesaver, people find it is a researcher of China academy of traditional Chinese medicine tu and her colleagues. Artemisinin discovery, on the basis of tu work, shandong, yunnan, guangdong, Beijing, Shanghai and other scientists who study unit has completed the structure identification, chemical synthesis of artemisinin, new drug research and development and large sample clinical research work, such as common achievement of artemisinin the significant results. Can be compared to, the contribution of tu researcher is "1", and the subsequent scientists behind the "1" added n "0", as "10000000..." Earlier, is a collective contribution makes artemisinin better benefit millions of malaria patients. Scientists group contribution to "523 project" are important. To artemisinin r&d is controversial, but how to evaluate the collective and individual contribution is the focus of debate for a long time. Since the beginning of the "1" is recognized, in accordance with the award selection criteria, tu, won the Nobel Prize in physiology or medicine without controversy, a researcher. , at the same time, the contribution of people can not be ignored as tu in his acceptance speech emphasized: the successful development of artemisinin and its derivatives is the collective to discover the successful example of Chinese traditional medicine, Chinese scientists who won the prize is the collective honor.

Artemisinin won Nobel Prize, science and technology system reform also has the enlightenment significance to our country. As member of the military academy of medical sciences dean he said, both of Chinese and traditional Chinese medicine, in the history of the Nobel Prize, is unknown, this gives our country's science and technology policy, science and technology as a cognitive challenge pattern, namely, not only in the field of hot, hot, hot in the direction of the region to create the world famous, the achievements of recorded history, we should not stick to one pattern to choose direction, selecting subject, support personnel, to perfect the market under the condition of the sports system, promote joint research, collaborative innovation, need to focus on personal subjective sex, advocating initiative, combine the role of the collective and individual well, build more flexible and diversified evaluation mechanism and incentive mechanism, mobilizing the enthusiasm and creativity of scientific research personnel, let more young people dedicate myself to the scientific research, promote the rapid development of science in China. Really doing these, the effect of no less than a Nobel Prize.

The original thinking of traditional Chinese medicine combined with modern science and technology to produce original work

"China if we have a contribution to the world, I see the doctor of traditional Chinese medicine is a." 62 years ago, chairman MAO zedong evaluation of traditional Chinese medicine, by today's standards, was prescient. Artemisinin won the Nobel Prize in physiology or medicine, and once again proved "the traditional Chinese medicine (TCM) is a great treasure", but need to "seek them, and to improve". The accumulation of thousands of Chinese medicine in one thousand, the essence and the dross, can be said to be a "treasure" has not yet been fully developed. As tu believes that Chinese medicine is a great treasure, but nor is it can use to pick up, you also need to innovation.

Traditional Chinese medicine (TCM) is never closed, is advancing with The Times, continuous development, absorb new knowledge and technical methods use different era. Contemporary, by leaps and bounds of science and technology, the development of Chinese medicine also needs to be combined with modern science and technology, constantly enrich its scientific connotation and era characteristics. Is an important field in our country with independent intellectual property rights of Chinese medicine, Chinese medicine unique theoretical system and original thinking, is not the source of scientific and technological innovation, contains a huge innovation potential. Original thought and the experience of traditional Chinese medicine combined with modern science and technology can produce original achievement, artemisinin research success is to follow this path. We advocate modernization of traditional Chinese medicine, not to say that the traditional is not important, explore the paths and methods of scientific and technological innovation of Chinese medicine, both must be good at looking for creative inspiration from the ancient classic medical books, also must be good at learning from the advanced science and technology. Traditional Chinese medicine combined with modern scientific theories and technical methods of penetration, can enrich the content of the life science, improve the ability of medical and health services, for the implementation of innovation driven development strategy, transformation of the mode of economic development to make greater contribution.

No need to stress is that traditional Chinese medicine and western medicine basic boundaries. Many western medicine is the result of natural herbal extracts, such as methamphetamine, berberine, papaverine, puerarin, hirudin and so on. Traditional Chinese medicine (TCM) play a role but also rely on chemicals, but chemistry is not the essence of traditional Chinese medicine, modernization of traditional Chinese medicine is still a traditional Chinese medicine (TCM), including compound, composition and monomer, also including different dosage forms. Artemisinin research success is a worthy of reference model, but is not the only model. The 21st century is the century of compound, the world on the basis of combinatorial chemistry, supported by the network pharmacology screening of drug combination, developed in view of the rapid development of the complex diseases drugs, emerging and developed compound drugs, traditional Chinese medicine (TCM) have an advantage, can lead the direction. Through the development of medicinal material, mechanism relatively clear components of traditional Chinese medicine, has successfully developed a number of modern Chinese medicine, classic square secondary development and achieved prominent progress. With the help of modern technology, to develop safe and effective, stable and controllable compound Chinese medicine is a direction of great potential.

Xi jinping pointed out: the inheritance of Chinese culture, is by no means a simple restore ancient ways, also is not blind xenophobia, but not limited, ocean for convenient, dialectical trade-offs, innovation, abandon the negative factors, inherit the positive thought, "with the rules of the ancients, open their dough", realize the creative transformation of the Chinese culture and innovative development. People of Chinese medicine must be self-confidence, self-improvement, little debate, much practice, limited and ocean for convenient, open mind to accept more subject to join in the study of traditional Chinese medicine to protect good, good study, make good use of this great treasure house of Chinese medicine, let the ancient Chinese medicine made new again. Also hoped the social from all walks of life to more fully understand and respect of Chinese medicine, in awe, cherish and respect national excellent culture heritage of prudent attitude, give a fair development environment of Chinese medicine. (the author zhang bl, the unit for the China academy of traditional Chinese medicine; Zhang Junhua unit of tianjin university of traditional Chinese medicine)