Beijing university tu pf team results

2015 national science and technology progress second prize

Date: 2016-01-11

 information sources: medicine

The morning of January 8, 2016, the party central committee and the state council was held in the great hall of the people in the 2015 annual national science and technology award. Xi jinping, li keqiang, the party and state leaders yun-shan liu, zhang gaoli attended the conference and to award on behalf of the award. College of Beijing university professor tu pf team to complete the research achievements of "based on the active ingredient in traditional Chinese medicine quality control technology and its application in medicine and safflower injection" won the national prize for science and technology progress prize 2015 (key persons involved: tu pf, Jiang Yong, li, bing-xiang zhao slope, Liu Shenghua, talk about English, history, Zhu Yaning, ming-bo zhao, Song Yuelin. Main complete unit: Beijing university, zhu san-jiu pharmaceutical co., LTD., jin co., LTD.). Professor tu pf, professor Jiang Yong and ming-bo zhao lecturer was invited to attend the meeting as a representative of the award-winning, tu pf "as the first persons to be leaders, such as the xi's collective interview, and took a group photo.

Professor tu pf (third left), and won t

he first prize in national science and technology progress prize winner yu dq academician (third from right), the second prize winner (left), professor kong ly pose at the scene of the meeting

It is understood that the project is to study the efficacy related active ingredients as the breakthrough point, based on the active ingredient of traditional Chinese medicine quality control in the whole series of new techniques and new methods, and successfully used for the quality control of medicinal herbs, yinpian, proprietary Chinese medicine, traditional Chinese medicine (TCM) significantly increased quality control level, promote the development of the traditional Chinese medicine standard system construction and related industries, made great economic and social benefits.

Traditional Chinese medicine (TCM) is the material basis for the prevention of traditional Chinese medicine clinical cure, also is the main material of our people's health care, in our country people's health and economic development plays an important role. To establish the quality control of traditional Chinese medicine effective method and evaluation standard, to ensure clinical medication safety effectively, enhance core competitiveness, promote the traditional Chinese medicine modernization and internationalization of traditional Chinese medicine (TCM) industry is of great significance. Chinese medicine has the function of attending widely, material base and complex composition, the characteristics of the multiple target effect, therefore, the overall quality control standards of TCM, which is the inevitable developing trend of Chinese traditional medicine quality standard.

For a long time, tu pf scientific research team for the efficacy of Chinese traditional medicine is widespread material is not clear, major ingredients and efficacy correlation is not strong, single index, or a few major ingredient content determination is difficult to effectively control its quality, chemical reference substance is a severe lack of key issues, such as in the "863" plan, major drug discovery special topics such as the support, to study the efficacy related active ingredients as the breakthrough point, to create the overall quality control of traditional Chinese medicines based on active ingredients series of new techniques and new methods, and successfully used for the quality control of medicinal herbs, yinpian, proprietary Chinese medicine, traditional Chinese medicine (TCM) significantly increased quality control level, promote the traditional Chinese medicine standard system construction and development of related industry. The main point of innovation research, application and social and economic benefit is introduced as follows:

One, the results of scientific innovations and scientific achievements

1, established the LC/DAD/MSn, NMR structure identification and high flux activity recognition with the combination of traditional Chinese medicine active ingredients quickly found that the new technology, improve efficiency of active ingredient research, clarify the 41 kinds of commonly used traditional Chinese medicine medicinal material, not only lay the material foundation for the quality standard building, also provide reactive molecules for innovative drug discovery and effective components.

The project will LC/DAD/MSn, nuclear magnetic resonance (NMR) structure identification combined with high flux activity recognition, established the Chinese medicine efficacy related components quickly found new technology; Built with the LC - MSn with independent property rights of traditional Chinese medicine composition mass spectrometry (LC - MSn - DS) database. Combined with fast chromatography, high-speed countercurrent chromatography and the preparation of high efficient separation means such as automatic liquid purification system, established the Chinese medicine efficacy related ingredients effective research system; Innovation is established by LC - DAD - MSn chemical composition of traditional Chinese medicines to record information database, active ingredients for traditional Chinese medicine to quickly find and rapid identification of target component efficient separation and metabolites provides a powerful tool. Project team USES the technology system of building, the vision, such as wood, dwarf lilyturf 41 kinds of commonly used traditional Chinese medicine material basis for the study of system, separate identification of compounds, 1901, which was first reported on international structure 311 new, enriched the Chinese medicine chemistry; Found that active compounds, 128, 12 strong mechanism of action of active compounds. The study not only to lay the material foundation for the establishment of relevant Chinese medicine quality standard, and provide reactive molecules for innovative drug discovery and effective components, promote the related disciplines and development of traditional Chinese medicine industry.

2, integration of advanced analysis techniques, active component of TCM, testing and evaluation of new technology and new method, overcome traditional Chinese medicine complex system efficiency analysis and the overall quality control, key technical problems for the quality of traditional Chinese medicine (TCM) has made an important contribution to the development of leading international standard.

Key problems in view of the overall quality control of traditional Chinese medicine, on the basis of clarify active ingredient/components, through the application of new technology and new means and methodology, research integration to establish the Chinese medicine complex system efficiency analysis and the overall quality control, a series of new technologies, to overcome the traditional Chinese medicine overall quality control, the key technical problems in leading Chinese medicine quality standard development direction: development of fingerprint testing and evaluation of new methods, leads the traditional Chinese medicine (TCM) fingerprint international development direction; New technology and new development of Chinese native medicine ingredient efficient analysis method, to overcome traditional Chinese medicine complex system analysis problem; Using PLE - HPLC, HPLC - CAD, ion chromatography technology to solve the Chinese native medicine ingredient extraction, separation and detection; Using 1 d and 2 d LC - MS/MS, in combination with more germplasm spectrum selection strategy, build efficient online for traditional Chinese medicine composition in vivo and in vitro qualitative and quantitative analysis technology; Based on the quantitative nuclear magnetic resonance (NMR) of traditional Chinese medicines (qNMR) metabolites omics analysis technology; Using extract contrast, quantitative mri (qNMR) to establish the content determination method, solve the problem of reference substance and the lack of traditional Chinese medicine inspection cost higher.

3, establish and perfect the technology based on active ingredients and the overall quality of medicinal materials, yinpian, proprietary Chinese medicine quality standard, comprehensively improve the quality of related traditional Chinese medicine, in order to ensure the security of clinical application and effective marketing support, implementation "science and technology leading standards development, promote industrial upgrade" goal.

Used to establish the quality analysis of the new technology and new method of active ingredients as indexes, set up and improve the quality of medicinal materials, and related injection and oral preparation standards, the system builds the 41 kinds of medicinal herbs and yinpian quality standard, set up 40 kinds of reference substance preparation methods and standards, set up four kinds of proprietary Chinese medicine fingerprint detection standards, completed five evaluation and standard injection to ascend; Established safflower and injection automatic online control production line, improve the product quality and clinical safety. To achieve the standard of "active ingredients - medicine - human diseases -" scientific transformation, realize "technology leading standards development, promote industrial upgrade" target, quality standards for traditional Chinese medicine research provides the demonstration.

Second, the application promotion

(1) the project set up 28 species medicinal materials, quality standards of income in 2010 and 2015 edition of Chinese pharmacopoeia, not only improved the related medicinal materials, quality standards, and provide demonstration standard for traditional Chinese medicine research and system construction. (2) to establish the fingerprint of radix bupleuri, radix astragali injection testing standard, completed the safflower, and wheat, ShuangHuangLian 5 kinds of injection and evaluation standard of pharmaceutical research and promotion, effectively guarantee the quality of the injection and clinical safety. (3) improve the locust ear grains, wide chest aerosol and other oral proprietary Chinese medicine and health care medicated wine "jin wine" quality standards, to improve and optimize the strength of the wine production process parameters and production lines, automatic production lines set up 20000 tons of health wine, effectively enhance and stabilize the product quality, provides the safe use of the product and market development of quality assurance. 18 (4) the project has licensed patents, a new drug for testing, published 200 papers, of which 86 SCI contains theses, SCI papers he cited 1088 times, Chinese papers he cited 1888 times. Effectively improve the quality of the related traditional Chinese medicine (TCM) of the project of standards, standards for traditional Chinese medicine to lead the international development has made important contributions.

Third, social and economic benefits

The project implementation, to establish the quality control of traditional Chinese medicines based on the active ingredient in innovative technology, for traditional Chinese medicine medicinal material efficiently to clarify and provides a effective method for quality control of whole traditional Chinese medicine (TCM). In the international famous magazine published related research achievements, promote the level of the quality analysis of traditional Chinese medicine and the international academic status. 41 kinds of commonly used traditional Chinese medicine active substance and the relevant mechanism to clarify, for the study of the related disciplines, clinical medicine and provide a scientific basis for deep development and utilization, promote the traditional Chinese medicine modernization. 128 the discovery of active compounds and some effective constituents for innovative drug discovery provides a new candidate molecules and efficacy components, injection with red stilbene producing approved clinical, effectively promote the innovative drug research and development. To extract for control of content determination and feature maps used in medicinal materials quality control, and income pharmacopoeia, improve the method is practical and scientific; 28 medicine yinpian, four medicine pharmacopoeia standard income and the national drug standards, completed the safflower injection and other famous Chinese patent medicine and health care medicinal liquor evaluation and standard to improve, improve the relevant product quality and the safety and efficacy of clinical application, the standard for traditional Chinese medicine research and system construction to provide demonstration, promote the development of the industry. Established in xinjiang safflower GAP base of 15000 mu, annual output value of 12 million yuan, promoting the local economic development and national unity.

The project training postdoctoral 4 people, Dr. 18 people, master of 15 people, including one for all, 1 person excellent green, three people in the ministry of education in the new century talents program, for the enterprise to cultivate a batch of high level talents of Chinese medicine, promote the development of the cause of Chinese medicine.

The implementation of the project greatly promote the clinical application of related products and market development, yoann san-jiu safflower, and injection of annual sales of 034 million yuan in 2007 growth in 2013 to 2.219 billion yuan. Strong brand strength of the wine with annual sales of 392 million yuan from 2003 growth in 2013 to 4.629 billion yuan; Nearly three years to realize direct economic benefit of 13.7 billion yuan, profit tax of 6.76 billion yuan, has achieved great economic benefit and social benefit.