Recently, shandong university of Chinese medicine affiliated hospital of the Chinese traditional medicine in assisted reproductive technology in basic and clinical translational research were the national women's and children's health science first prize of scientific and technological achievements, experts say the result for the promotion mechanism of eugenic and superior nurture research of traditional Chinese medicine set up a new platform --

Traditional Chinese medicine for infertility family add "life",

Time: 2016-03-17

Source: China's traditional Chinese medicine

Author: Lin Xiaofei

Two child policy full liberalisation of the first spring, comes at a time when the last time the baby in the year of the monkey, in the shandong university hospital of traditional Chinese medicine combine traditional Chinese and western medicine clinic center for reproductive and genetic, looking forward to good "pregnant" couple more than usual, most of them come. "Listen to the friend say the same for test-tube baby, here is different from other hospitals." Had two test-tube baby Joe failure of the woman and her husband decided to come to the director for help.

Chinese medicine can be incorporated into the modern assisted reproductive technology, increase the rate of infertility patients with pregnancy, shandong university hospital of traditional Chinese medicine "for SongZi" is attracting more and more like Joe ms patients.

"For SongZi" scientific validation

Affiliated hospital of shandong university of TCM in the famous hospital preparations "two to menstruation particles", as a "for SongZi" by many infertility patients. Once, a couple had been married for 5 years without a child couples come to combine traditional Chinese and western medicine, director of the center for reproductive and genetic even make a diagnosis and give treatment, their painful memories cause of infertility: premarital once a medical abortion and married three embryos TingYu is done, after his wife endometrial uterine cavity adhesion, damaged, menstrual quantity is little and even amenorrhea. Even think this kind of circumstance belongs to the kidney, so first "two to menstruation party" joint repair jiale, progesterone application 2 cycles to repair the damaged endometrium, reoccupy ultrasound monitoring follicle cycle, and continue to give "two to menstruation party" and "ginseng and astragalus shou fetal pill", to zi kidney nourishing the liver and regulating chong ren, let patients kidney is adequate, ren tong sheng. Such treatment to the third menstrual cycle, the wife is pregnant, and safe production of the following year.

"For SongZi" in clinical application of success stories abound. Even party, think the kidney stores essence of traditional Chinese medicine, the main reproductive, kidney essence with subtle substances, menstruation is to promote reproduction is the source of the egg development. Kidney deficiency is the basis of the egg cell developmental disorders and pathogenesis. The study found that "invigorating the menstruation, nourishing blood DiaoChong" has obvious promoting effect to reproductive function. "Two to menstruation party" is based on the above theory consists of fructus ligustri lucidi, dry lotus grass, medlar, dodder 10 kinds of traditional Chinese medicine (TCM).

"For SongZi" good clinical curative effect, also won the validation of the evidence-based medicine clinical trials. Even the party leading group for about nine years, over 3000 of in vitro fertilization (ivf) to carry out large sample randomized controlled trial, patients with confirmed "two to menstruation particles" assisted effect obvious reason has 3: obviously improve the infertility patients of kidney deficiency syndrome; Improve the ovaries to stimulate ovulation drugs of reactivity and egg maturity; Improving egg follicle before blood supply, improving the quality of the egg, egg number and rate of high quality rate of eggs and embryos.

Improve the success rate of "test-tube babies" of traditional Chinese medicine

In vitro fertilization - embryo transfer (IVF - ET) the rapid development of technology for infertile women. However, a large number of applications of super ovulation drugs in pregnancy rates increase IVF - ET at the same time, also brought a series of complications, such as affecting the egg quality, endometrial development are not synchronized, cause ovarian hyperstimulation, etc. And the current birth rate is low, the technology of high cost.

In order to solve the hot and difficult problem of reproductive medicine, even the party lead the team to begin from 2005, in the 4 projects from national natural science fund support, with the concept of basic and clinical research, combines traditional Chinese medicine and western medicine of assisted reproductive technology, mainly in three aspects of research, adjust the study of syndromes; From the perspective of a variety of "omics" kidney deficiency of TCM standardization were discussed; "Acupuncture + pelvic physiotherapy" improve the receptivity of endometrium, and "two to menstruation party" help pregnant does systemic research on the mechanism of action.

For secondary infertility caused by a disease, also can through the method of effective treatment of traditional Chinese medicine. Such as patients with endometriosis cause infertility, even the party put forward the pathogenesis of endometriosis "stasis poison" theory, developed the "quyu jiedu party", and confirmed that the party can strengthen the stability in ectopic, reduce its lining and ectopic endometrial adhesion, thus inhibiting the grown within the pelvic adhesion, effective in the treatment of endometriosis, improve the success rate of in vitro fertilization and embryo transplantation patients. For patients with embryonic plant failed repeatedly, the team through several studies have demonstrated that using traditional Chinese medicine (TCM) with pelvic physiotherapy, acupuncture point stimulation can improve the blood supply of the endometrium and receptive, effectively improve the success rate of "test-tube babies".

On 19 February this year, even the research achievements of party and his team "of traditional Chinese medicine in the assisted reproductive technology transformation of basic and clinical research were the national women's and children's health science first prize of scientific and technological achievements, experts say the results for the promotion mechanism of eugenic and superior nurture research of traditional Chinese medicine to build the new platform.

Research results enrich reproduction theory of TCM

Through literature and experimental research for many years, the team with the same results enrich the traditional Chinese medicine theory in the field of reproduction. For example, through to the 200 ivf drop to adjust to literature research, case and with medicine test certificate, found falling tone after the performance of the patients with kidney Yin deficiency syndrome is given priority to, super ovulation after the performance of the patients with kidney Yin deficiency and disorder is given priority to. The results to fill the regulation of traditional Chinese medicine in the fall, the respect such as super ovulation syndrome of blank, supplement developed with the theory of TCM syndrome of department of gynaecology.

Again, such as, "groups" of traditional Chinese medicine theory is that "women's kidney, seven more hair long tooth. Erqi menstruation come, ren meridian, lr 3 veins, flow in nowadays, so a child... groups ren meridian, lr 3 less failure of arteries and veins, menstruation, tunnels, so bad and no son". The team through the study of kidney deficiency syndrome and the correlation of ovarian reserve, from molecular and genetic level for infertility in aged patients of kidney empty performance provides the basis of the microcosmic syndrome differentiation, reveals the scientific connotation of TCM theory of "groups".

On "two to menstruation particles" mechanism and improving the quality of the egg, the team confirmed follicular fluid for kidney essence, "particle" two to menstruation is by adjusting the follicular fluid metabolism and Ca2 +, concentration of cholinesterase, creatinine, increased egg Ras protein expression of the effect of improving the quality of the egg, and enrich the TCM theory of "kidney main reproductive".

The research achievements of this series has the initiative also attracted international attention. In 2013 the party was invited to the American society for reproductive medicine in Boston, USA (the ASRM presents) 69th annual meeting, "traditional Chinese medicine in the application of assisted reproductive technology" of the latest research achievements attracted the attention of foreign experts. For many western scholars' concerns, even the quality of traditional Chinese medicine, acupuncture, physical therapy to female egg and the receptivity of endometrium in this paper, the effect of do let international reproductive medicine to realize in the promotion of traditional Chinese medicine plays an indispensable part in the development of assisted reproductive technology.

Transformation and application of research results only through, to improve the ultimate goal of clinical curative effect, at the same time, communication is the necessary way to improve the social and economic benefits. Every year since 2004, the group held a national continuing education activities, communicate project results and clinical application. Over the years, the party and its team of research learning, promote the domestic numerous hospital, for more families had brought a "life" of the next generation.