Dense floweyes Chinese medicine er power dry new drug research and development

Content source: China's traditional Chinese medicine

Densely covered flower extract eye drops can significantly inhibit the occurrence of androgen levels caused by dry eyes, its mechanism of action can inhibit lacrimal apoptosis

Dry eyes because of the high incidence, treatment more difficult, it is current research hotspot issues. Qing-hua peng of hunan university of Chinese medicine, xiao-lei yao and leffler, completed the basic research of flower extracts in the treatment of dry eyes, "2015 annual" kang yuan cup "won the first prize in the science and technology prize of China association of Chinese medicine, to guide the clinical treatment of dry eye has a good application prospect, and the research and development is of important guiding significance for Chinese traditional medicine new drug for the treatment of the disease.

In the numerous possible causes of the disease, androgen levels drop is one of the most important reason. Research found that densely covered flower extract preparation into eye drops to treat experimental dry eyes, also has a partial cell apoptosis inhibition effects of androgen. Team, supported by the national natural science fund projects such as, the study is to discuss the secret flowers to androgen effects of total flavonoids as the breakthrough point, using three kinds of drug levels (dense flowers preliminary extract, effective parts, eye drops) from the two aspects of in vivo and in vitro to have curative effect and its mechanism of action of flower extracts in the treatment of dry eyes held in-depth and systematic research, the research and development of innovative drugs of Chinese medicine treating dry eye has a positive role.

Guangzhou university of Chinese medicine professor zhi-ying li said that the results of the study of creative contribution lies in: first use of densely covered flower extracts (including effective parts) to treatment of androgen level of androgen effects which can be caused by dry eyes of scientific hypothesis, and USES the kinetics of receptors, receptor pharmacology and molecular biology combined with experimental study confirmed; The project from Angle of androgen and intervention mechanism of lacrimal gland cells, explore the effective parts densely covered flower treatment mechanisms and pathways of androgen disorders caused by dry eyes, both at home and abroad, there is no relevant research reports; The project from a variety of etiology, symptoms, densely covered in the view of molecular biology, and other flowers in the treatment of sex hormone levels drop caused by dry eyes to study the therapeutic effect and its mechanism, in the first time in the industry at home and abroad.

Chengdu university of traditional Chinese medicine professor xue-jun xie pointed out that the research purpose, research scheme design is reasonable; Experimental research method is advanced, reliable data and reliable conclusions, scientific, innovative and advanced nature, not only for dry eyes and combine traditional Chinese and western medicine treatment in TCM research provides a new train of thought and method, and dry eyes for clinical treatment provides a new effective treatment method, has good application value and prospect, and literature novelty search in novelty search range, the densely covered flowers flavonoids extracts or densely covered the basic experiment study of androgen levels drop caused by dry eyes unless the project declare publicly reported at home and abroad and its team members, not to have the relevant public reporting of others. As a result, the achievements in the international advanced level of similar research.

It is reported, the study has been in professional core journals published 36 papers, including 1 SCI article, and widely quoted by domestic and foreign counterparts, were cited 249 times; Research by national planning for graduate students in higher colleges and universities of Chinese medicine materials and the ministry of health of the eleventh five-year plan teaching ophthalmology of traditional Chinese medicine clinical research adopts, one was awarded the first prize for science of traditional Chinese medicine of hunan province, hunan province natural science in item 1, 2 application for invention patents. (the author: Zhou Manyi)