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Chinese medicine treatment of diabetes according to evidence

Time: 2017-02-23

  At present, the diagnosis and treatment of diabetic nephropathy is difficult to early occult onset, difficult to diagnose, lack of effective treatment of dominant proteinuria, rapid progress to uremia. Chinese medicine in the treatment of diabetic nephropathy proteinuria accumulated a certain degree of clinical experience, but the lack of high-quality evidence-based medicine, the lack of quantitative and objective evaluation of the indicators, the mechanism of drug action is not clear, limiting the Chinese medicine at home and abroad The promotion and application.

  By the Sino-Japanese Friendship Hospital Pharmaceutical Pharmacology Research Director Li Ping led the completion of the "Yiqihuoxue treatment of diabetic nephropathy dominant proteinuria clinical and basic research" recently won the 2016 National Science and Technology Progress Award two prize. This study demonstrated the exact effect of Yiqi Huoxue Recipe on the treatment of diabetic nephropathy, and found that the metabolic markers related to qi deficiency and blood stasis were established. The systematic evaluation system of diabetic nephropathy was established, which revealed that Yiqi Huoxue Recipe The mechanism of treatment of dominant proteinuria in diabetic nephropathy.

  18 years to create innovative results of Chinese medicine

  "The project's research lasted for 18 years." Li Ping, head of the project, said that the project team in the National Science and Technology, the National Natural Science Foundation of China and other topics support the diabetic nephropathy for clinical and basic series of research, made a number of innovative achievements The

  On the basis of the experience of traditional Chinese medicine, combined with team literature research, Delphi method expert survey and cross-sectional study and other results, the project found that diabetic nephropathy protein protein pathogenesis of kidney and liver stasis, Closed resistance The method of "Yiqi Rougan Huoxue Tongluo" is a new method for the treatment of diabetes mellitus, which is a new method for the treatment of diabetic nephropathy. It has a good clinical effect for the diabetic protein of diabetic nephropathy.

  In addition, the study also conducted six centers, randomized, double-blind, placebo-controlled clinical trials. Experimental results show that the glycemic side of the treatment of dominant proteinuria effective rate increased by 30%, so that the efficiency of treatment of glomerular filtration rate increased by 11%, breaking the diabetic nephropathy protein protein treatment threshold. The results of the study published in the international community, is so far published by the Chinese medicine treatment of diabetic nephropathy high evidence of evidence-based medicine.

  In order to objectively evaluate the clinical efficacy of Tangxian Decoction in the treatment of diabetic nephropathy, the research team established a quantitative metabolomics study model that integrates metabolomics and target metabolomics. And then use the correlation analysis found that Yin deficiency blood stasis, qi deficiency blood stasis and yin and yang deficiency syndrome metabolic markers. Which inosine, xanthine, cytosine and other diabetic nephropathy dominant proteinuria corresponding to the representative signs of Qi deficiency and blood stasis. The metabolic changes of Tangxian Decoction in the treatment of diabetes mellitus were measured by the above key indexes, and the metabolites were found to be close to normal after drug treatment. At the same time, the team first discovered changes in the concentration of inosine in the blood, can predict the risk of diabetic nephropathy, creating a diabetic nephropathy "disease-card combination" clinical diagnosis and efficacy evaluation of integrated biomarker system.

  Application of System Biology to Traditional Chinese Medicine Research

  The research team also published "Systems Biology for Traditional Chinese Medicine" on the basis of the study, which is the first "biology monograph of the first Chinese medicine system".

  "This book's innovative application of systems biology to Chinese medicine research will accelerate the promotion of cooperation and communication between Eastern and Western scientists." John Wiley & Sons Inc, the publisher of the book. This monograph is highly praised, saying that this monograph based on chemical substanceology, genomics, proteomics, metabolomics and other multi-group platform, from the molecular level and system level to explain the mechanism of Chinese medicine, for Westerners It is useful to understand Chinese medicine (and other traditional medicine) and traditional Chinese medicine researchers to understand the relevant modern science and technology.

  It is reported that the promotion and application of scientific research results are also commendable, the results were in 40 hospitals to promote the application, improve the clinical efficacy of delayed diabetic nephropathy patients into the end of the time of kidney disease, improve the quality of life of patients, saving Medical expenses. The project team published 210 research papers, which were included in the SCI 64, the cumulative impact factor 159.076 points, the total cited 1042 times, the highest single cited 88 times; published monograph 3; won the national invention patent 2; Research approval 1; provincial and ministerial level scientific and technological achievements first prize 3, second prize 4.

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