Traditional Chinese medicine borneol topical analgesic action mechanism was verified

Time: 2017-04-21

Source: China's traditional Chinese medicine

Author: England

Report from our correspondent recently, kunming institute of zoology, Chinese academy of sciences ion channel drug research and development center in collaboration with Shanghai changzheng hospital, first carried out in accordance with international standards of borneol clinical research, illustrates the topical analgesic action mechanism of traditional Chinese medicine borneol, the total number of 122 people to enroll in clinical trials.

Borneol is a common Chinese herbal medicine, Chinese medicine clinical application of more than one thousand years. Natural Borneol is to obtain the lauraceae plants nearly pure monomer crystallization of organic compounds, its chemical composition is (+) - Borneol, belongs to small molecule terpenoids. Borneol "taste hard, cold," it is a important effect "" acetanilide detumescence, can be used for outside" ulcers sore "pain" segments ", etc. But for a long time, the clinical efficacy of topical borneol analgesia lack of international standard (randomized, placebo-controlled, double-blind trial) experimental data of the human body, the analgesia mechanism of science also has not been elucidated. The us food and drug administration for a long time will borneol as food additives, and not as a drug use.

Researchers through randomized controlled double-blind clinical trial in the placebo group, prove topical borneol on postoperative wound pain good analgesic action. Then through the pain signaling pathways in different molecular targets screening, prove TRPM8 ion channels on peripheral neurons is ever discovered mammal of borneol in the body is the most sensitive targets. Through further pain in mice model was established, blocking TRPM8 gene knockout mice and pharmacology experiment, prove topical analgesic action of borneol is mainly mediated by TRPM8 channels. Borneol activation TRPM8 peripheral neurons after activating the spinal cord dorsal horn presynaptic glutamate receptor metabolic type, eventually leading to pain inhibition of neural signal transmission. The study provides for the first time in line with international standards of topical borneol analgesia clinical research data, illustrates the role of cell and molecular mechanism, the development and modernization of the traditional Chinese medicine borneol is of great significance towards the world.

The results of the study, published in the EMBO Molecular Medicine, associate professor wang, kunming animals graduate Hu Jinsheng and Shanghai changzheng hospital, Dr Zhang first author together for the article. Kunming animals associate professor wang, researcher England and Shanghai changzheng hospital professor jian-ru xiao for articles corresponding author.

The study got department of yunnan province, the national natural science foundation and ministry of science and technology support project "973" and so on many funds. (England)