Focus "pearl river BBS" (next) how to ensure safety problems tcmi? How to develop component Chinese traditional medicine research? How to establish toxic medicine standards? As "the pearl river BBS" participating experts debated --

Traditional Chinese medicine innovation

development key problem how to crack

Our correspondent to the good

     Tcmi safety issues lead concern

    "The security problem of tcmi to TCM products have been caused by the masses of trust crisis, we must strengthen the scientific research work!" Recent reports of adverse drug reactions is increasing, Chinese traditional medicine adverse reactions become public opinion in the second focuses on hot, pearl river BBS, YaoXinSheng academicians so appeal.

    Chinese medical academy professor says YeZuGuang, 75% of the traditional Chinese medicine adverse reactions, and from tcmi percent of them all again is allergic reaction. Tcmi allergic reaction is facing the focus, academic research bottleneck.

   Traditional Chinese medicine composition more, the composition and toxic ingredients and effective components not entirely clear wait for a reason, so in foreign scholars looks like "tcmi allergic reaction caused the allergy source material base is not clear". Plus Chinese medicine production process uncertainty factors make the drugs more difficult total quality control.

    YeZuGuang tcmi should believe, to carry on the omni-directional system research, including pharmacy quality control, process, agents, on this basis, the good production shut in tcmi clinical find out the reasonable application, advantages and characteristics.

    The Chinese academy of medical sciences institute of medicinal plants SunXiaoBo professor says that many tcmi production particularly large, but different batches of medicinal materials in tcmi are not stable in quality, another most tcmi is old injection, process many disadvantages exist, so the raw materials and accessories for the guarantee injection quality is the key link. Due to different, complementary makings or match tcmi liquid in use process also can produce adverse reactions, the control of raw materials, auxiliary materials, process and methods for testing and clinical use, in the short term tcmi was obviously improved.

    Component is critical medicine research selected square

    Components of the anthranilic research is Chinese ZhangBoLi multidisciplinary innovation in the academician of Chinese medicine research suppositions mentioned in one of five research direction, also become the pearl river BBS attendants at debated content.

    The so-called Chinese herbal medicines, "a composition from prescription, separated after technical research; another kind from single herb compatibility, through on to a certain disease and syndrome form components." ZhangYongXiang military academy of medical sciences professor said.

    Tianjin university of traditional Chinese medicine GaoXiuMei professor argues that traditional Chinese medicine must be from components of an effective agent for clinical and pathologic process and the disease targets and material base relatively clear-cut, can repeat preparation, standardization of the effective components, compatibility of existing synergistic effect reduced poison, and finally achieve the rationalization of quality is controllable, dosage form.

    SunXiaoBo also think, traditional Chinese medicine research key components is the choice of classic clinical effectiveness, "herbal prescriptions, much more than the research target ingredients must revolve around for TCM compound related disease and syndrome of research, avoid some study only pursue simple ingredients and targets, and ignore the disease and syndrome related-party effect, supplemented by the effective components for disease and syndrome of the association, to reflect the overall effect the anti-hypoxia effect." SunXiaoBo said.

    To study how to develop, Shanghai university of TCM ChenKaiXian academician were principal, and can be used modeling and MoNiHua method based on the effective components in TCM formula of quantitative design research, herbal medicines, including components. "Strengthening the TCM group of research solve the above problem is very good point, and through the research to understand the material base, mechanism, compatibility of the law, can promote new-type compound Chinese medicine developed." ChenKaiXian said.

    Chinese medicine academy of traditional Chinese medicine, professor 4 Suggestions in more research should be components of clinical process into bioinformatics method, and the disease linked to the basic targets network, etc.

    Toxic Chinese traditional medicine research is still inadequate

    The modernization of traditional Chinese medicine for many years in efficiency, quality control and has a lot of achievements, but unfortunately, as the basis of the industry of Chinese medicine, Chinese medicine yinpian systems toxicology research is still serious insufficiency. How to further develop toxic TCM study, how to 1025 "in" major national drug under the framework of cooperative research &develop new substantial breakthrough, also become many experts concern.

     National ZhongZhi pharmacopoeia commission money tells a reporter, Chinese medicine, professor of international cooperation process, standard is a commanding heights. "We are setting up, with foreign cooperation with foreign experts negotiations, meet's biggest bottleneck is safety issues". In Chinese medicine, Chinese pharmacopoeia toxicity study is also the awkwardness of the situation at present. "China pharmacopoeia for 60 years history, including big poison, toxic, posted a small poisonous three types of traditional Chinese medicine can sign for reference only, because it is based on experience in materia, no modern research data support." Money ZhongZhi said. ZhangBoLi also says, poisonous medicine research is one of the traditional Chinese medicine study some problems, although countries have been given support, but lack of systems research, lack of uniform standards of international standard.

     The fear is that our country's at present commonly used nearly 500 kinds of Chinese traditional medicine, can get a system of research literature toxicology and safety less than 3%; China pharmacopoeia monographs of toxic Chinese herbal medicine, 31, small poison toxic 42, big poison nine, but can get there is relative system only 15 kinds of toxicity study.

    The experts agree, Chinese traditional medicine research into the "toxic 1025" multidisciplinary innovation framework of TCM study of China pharmacopoeia monographs, first marked toxicity herbs and yinpian, developing system standard GLP toxicity assessment research, make clear poison quantity relationship, poison structural-activity relationships, determine the safety of toxic dose, safe drug use time and frequency, etc. Secondly, explore systems biology auxiliary conventional toxicological study way, with conventional toxicological primarily, by use of system biology including metabolism, group ways to learn, etc, this toxic components, the correlation between the toxic target organ.

    "Chemical and pharmacology and toxicology combining multidisciplinary, puts forward and formulate the toxicity of medicinal quality control. At the same time limits research achievements in China pharmacopoeia to load, and finally establish a set of scientific, authority, systematic and standard common Chinese herbal medicine and yinpian toxicology safety database." Money ZhongZhi said.

    Chinese medical academy of institute of Chinese medicine, Chinese medicine HuangLuQi professor considered toxic issues closely related with doses, should be in pharmacopoeia dose and clinical doses of choice neo-virginity.

     Guangzhou university of traditional Chinese medicine, professor LaiXiaoPing proposed in toxicology of methodology, besides using modern pharmacology and toxicology of method, attention should also be paid to the study of TCM characteristic, especially in combination with medicinal properties when toxicity.